10-week Yoga Practice Effect on Cognitive and Motor Function in Older Adults

Aging Clinical Trial

— BDNF  

Official title:

10-week Yoga Practice Effect in Older Adults

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04314921
• Other study ID #: LithuanianSportsU-3
• Status: Completed
• Phase: N/A
• Start date: October 1, 2018
• Est. completion date: September 30, 2019

Study information

• Verified date: March 2020
• Source: Lithuanian Sports University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Thirty-three healthy elderly people, who were classified into two age groups, participated in this study. All participants had not practiced yoga before and were asked not to perform any sports activities while the research was ongoing. In the experimental group, participants (n = 18) had to participate in 10 weeks of yoga classes. In the control group, participants (n = 15) did not perform any exercises or other changes in their daily living life.

Experimental measurements: Brunel, PSS-14 and HAD questionnaires

Recruitment information / eligibility

• Status: Completed
• Enrollment: 33
• Est. completion date: September 30, 2019
• Est. primary completion date: September 30, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 60 Years to 76 Years

Eligibility

Inclusion Criteria:

• age, from 60 years old

• a statement by a local family physician about general good physical health

• never tired to practice yoga before

Exclusion Criteria:

• cardiovascular diseases

• musculoskeletal system diseases (osteoporosis, osteochondrosis, hernias)

• neurodegenerative diseases

• oncological diseases

• glaucoma

• injuries and surgeries in last 3 years

Related Conditions & MeSH terms

• Aging
• Healthy Aging

Intervention

Other:
• Yoga trainings
10-week yoga sessions, 2 times per week, 90 min per session.

Locations

Country	Name	City	State
Lithuania	Lithuanian Sports Unviersity	Kaunas

Sponsors (1)

Lead Sponsor	Collaborator
Lithuanian Sports University

Country where clinical trial is conducted

Lithuania, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Brunel mood scale (BRUMS)	The Lithuanian translated version of the Brunel Mood Scale (BRUMS) was used in the present study. It was based on the originally developed to serve as a brief measure of mood before and after yoga intervention. The BRUMS (1) scale has 24 items arranged into six subscales: anger, confusion, depression, fatigue, tension and vigor. Each subscale has a numerical rating scale (0 = not at all, 1 = a bit, 2 = moderate, 3 = enough; 4 = extremely) from which research participant select the one best represents at that time. The results within subscale is summed and a score range from 0 to 16	10 weeks
Primary	Hospital anxiety and depression scale (HADS)	To determine the level of anxiety and depression of subjects was used HADS scale. The scale consists of totally 14 questions with the answers valued from 0 to 3. Half of questions addressed to estimate anxiety and rest - depression. The total scoring and conclusion for the both categories of questions: 0-7 = Normal; 8-10 = Borderline abnormal (borderline case); 11-21 = Abnormal (case)	10 weeks
Primary	Perceived stress scale -14	The purpose of this scale is to assess the degree of stress in subjects' lives. It consists of questions about the frequency of feeling and thoughts during the past time period. Potential answers: 0-never; 1-almost never; 2-sometimes; 3-fairly often and 4-very often. The scores are obtained by reversing the scores on the four positive items: for example, 0=4, 1=3, 2=2, etc. and then summing across all items. Scores for the 14-item form range from 0 to 56, with higher scores indicating greater perceived stress	10 weeks
Primary	Human Free BDNF	Venous blood samples from median antecubital vein were collected in 5 ml vacuum tubes with a gel separator and was separated by centrifugation (15 min at 1200g) to make blood serum. Samples were aliquoted and stored at -800C until analysis. The serum concentration of Human Free BDNF was measured using an enzyme-linked immunoassay kit (R&D Systems, Minneapolis, USA)	10 weeks
Primary	Measurement of cognitive functions	Automated Neuropsychological Assessment Metrics Version 4 (ANAM-4; Vista Life, USA) was used to measure neurocognitive skills: mental flexibility, verbal working memory, inhibition control, visuospatial processing.	10 weeks
Primary	Psychomotor function evaluation	Participants were assessed by Dynamic Parameter Analyzer (DPA-1). Its measure motor functions: accuracy, reaction speed-accuracy.	10 weeks
Primary	Heart rate variability	R-R intervals were recorded using a Polar H7 sensor with a chest strap (Kempele, Finland).	10 weeks
Primary	Balance procedure	Postural sway activity was measured by a posturography method with a single piezoelectric force plate (Kistler, Slimline System 9286, Switzerland).	10 weeks