Aging Clinical Trial
Official title:
Physical Fitness as Klotho Protein Stimulator; Antiaging Effects of New Training Methods (FIT-AGING).
FIT-AGING will determine the effect of different exercise modalities on α-Klotho protein (primary outcome) in sedentary healthy adults. FIT-AGING also investigate the physiological consequences of activating Klotho gene (secondary outcomes).
Aims: The plasma Klotho protein concentration (α-Klotho protein), which is considered a
powerful biomarker of longevity, makes it an attractive target as an anti-aging therapy
against functional decline, sarcopenic obesity, metabolic and cardiovascular diseases,
osteoporosis, and neurodegenerative disorders. Physical exercise and physical fitness, could
be α-Klotho protein activators through biochemical process. FIT-AGING will determine the
effect of different exercise modalities on α-Klotho protein (primary outcome) in sedentary
healthy adults. FIT-AGING also investigate the physiological consequences of activating
Klotho gene (secondary outcomes).
Methods: FIT-AGING will recruit 60 sedentary, healthy, adults (50% women) aged 40-65 years.
Eligible participants will be randomly assigned to a non-exercise group to the usual control
group (n=15), physical activity recommendation from American College of Sport Medicine, World
Health Organization and American Heart Association group (n=15), High Intensity Interval
Training group (n=15)) and Whole-Body Electromyostimulation group (n=15). Laboratory measures
completed at baseline and 12 weeks later, include α-Klotho protein concentration, physical
fitness (cardiorespiratory fitness, muscular strength), body composition, resting metabolic
rate, hearth rate variability (HRV), health blood biomarkers, free-living physical activity,
sleep habits reaction time, cognitive variables and health-related questionnaires. The
investigators will also obtain dietary habits data and cardiovascular disease risk factors.
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