Effect of L-Citrulline on Vascular Function

Aging Clinical Trial

Official title:

Impact of Reduced Arterial Stiffness on Peripheral Vascular Function and Mobility

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03127917
• Other study ID #: 15BGIA22710012
• Status: Completed
• Phase: N/A
• Start date: July 2015
• Est. completion date: December 31, 2017

Study information

• Verified date: May 2018
• Source: Texas Tech University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The objective of this project is to determine the importance of peripheral vascular function on gait performance in older adults.

Description:

This project employed a placebo controlled, double-blind, crossover trial. Participants were randomized to oral L-citrulline (6 g/day) or placebo (maltodextrin) for 14 days, and switched to the other treatment for another 14 days after washout. Peripheral vascular function was assessed under conditions of rest, leg exercise, and cognitive engagement. Gait performance was assessed using clinical walking tests.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 25
• Est. completion date: December 31, 2017
• Est. primary completion date: March 22, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 60 Years to 79 Years

Eligibility

Inclusion Criteria:

• older adults

• women and men

• aged 60-79 yrs

• must be able to swallow capsules

• fully mobile without assistive walking devices

Exclusion Criteria:

• have physician diagnosed cardiovascular, pulmonary, or metabolic disease

• are current smokers

• currently taking medications affecting cardiovascular function

• have high blood pressure (>159/99 mmHG)

• have high fasting blood glucose (>110 mg/dL)

• are considered obese (body mass index = 30 kg/m2)

• have orthopaedic limitations that limit walking ability

• have pacemaker or other metal objects in their body

Related Conditions & MeSH terms

• Aging
• Blood Flow
• Citrulline

Intervention

Dietary Supplement:
• L-citrulline
L-citrulline capsules given at 6 g/day

Other:
• Placebo
Maltodextrin capsules given as placebo

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
Texas Tech University	American Heart Association

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Blood Flow	Femoral blood flow during leg exercise and carotid blood flow during mental activity measured using Doppler ultrasound. Blood-oxygen-level dependent contrast imaging of the brain using functional magnetic resonance imaging (fMRI) during cognitive functioning.	baseline and 2 weeks for L-citrulline and placebo
Secondary	Gait Performance	Usual and fast walking speeds measured during short (7m) and long (400m) distances.	baseline and 2 weeks for L-citrulline and placebo