Aging Clinical Trial
Official title:
Neuroplasticity in Adulthood: Physical Exercise and Cognitive Training; Integrative Omics Study on the Neurobiological Effects of Physical Activity and Cognitive Stimulation
Verified date | October 2018 |
Source | University of Barcelona |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The MoveMent project applies non-pharmacological strategies - physical exercise and cognitive training - that have been shown to be effective in promoting active and healthy aging. The objective is to study the molecular and neural mechanisms of these strategies to stimulate brain plasticity and improve brain health and cognitive functioning.
Status | Completed |
Enrollment | 110 |
Est. completion date | April 8, 2018 |
Est. primary completion date | April 8, 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 50 Years to 70 Years |
Eligibility |
Inclusion Criteria: - Age between 50 and 70 - Underactive or sedentary (<2 hours a week of physical activity). - Adequate visual, auditory and fine motor skills. - Able to speak and understand Catalan or Spanish language. - Accept to take part in the study and sign the informed consent according to the Declaration of Helsinki. Exclusion Criteria: - Mini mental State examination < 24 and Montreal Cognitive Assessment- Short (MoCA -S) < 6. - Diagnosis of mild cognitive impairment, dementia or other serious neurological, psychiatric, or systemic illness. - Presence of another illness that render them unable to engage in physical activity (signs or symptoms of chronic heart disease, chronic obstructive pulmonary disease, orthopedic problems). - History of drug abuse or alcoholism. - Psychotropic consumption - Contraindication to magnetic resonance imaging |
Country | Name | City | State |
---|---|---|---|
Spain | Centre Atenció Primària el Maresme | Mataro | Barcelona |
Lead Sponsor | Collaborator |
---|---|
University of Barcelona | Germans Trias i Pujol Hospital, Institut Guttmann, Jordi Gol i Gurina Foundation, Ministerio de Economía y Competitividad, Spain, Universitat Politècnica de Catalunya, University of Pittsburgh |
Spain,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Changes in global cognitive function | Mini mental state examination | Baseline and 3 months | |
Primary | Changes in functional and structural brain plasticity assessed with Magnetic Resonance Imaging | Resting state connectivity, structural connectivity, white matter integrity, tractography, volume of white and grey matter structures. | Baseline and 3 months | |
Secondary | Changes in cognitive function | Tests of executive function, attention, memory, language, visuospatial abilities and speed | Baseline and 3 months | |
Secondary | Changes in emotional and functional status: Cognitive decline | Short Form of the Informant Questionnaire on Cognitive Decline in the Elderly (Short IQCODE) | Baseline and 3 months | |
Secondary | Changes in emotional and functional status: Depression | Geriatric Depression Scale (GDS) | Baseline and 3 months | |
Secondary | Changes in emotional and functional status: Mood | Adapted Visual Analog Mood Scale (VAMS) | Baseline and 3 months | |
Secondary | Changes in emotional and functional status: Clinical outcome | Spanish version of the Clinical Outcomes in Routine Evaluation - Outcome Measure (CORE-OM) | Baseline and 3 months | |
Secondary | Changes in health, fitness and physical activity: Cardiovascular risk factors | Cardiovascular risk factors | Baseline and 3 months | |
Secondary | Changes in health, fitness and physical activity: Sleep | Pittsburgh Sleep quality Index | Baseline and 3 months | |
Secondary | Changes in health, fitness and physical activity: Physical activity questionnaire | Spanish version of the reduced Minnesota leisure time physical and activity questionnaire (VREM) | Baseline and 3 months | |
Secondary | Changes in health, fitness and physical activity: Fitness | One-mile Rockport walk test | Baseline and 3 months | |
Secondary | Changes in health, fitness and physical activity: Physical activity monitoring | Polar Loop activity monitoring device. | Baseline and 3 months | |
Secondary | Changes in metabolites and gene expression patterns | Metabolomic and transcriptomic analyses | Baseline and 3 months |
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