Aging Clinical Trial
Official title:
Neuroplasticity in Adulthood: Physical Exercise and Cognitive Training; Integrative Omics Study on the Neurobiological Effects of Physical Activity and Cognitive Stimulation
The MoveMent project applies non-pharmacological strategies - physical exercise and cognitive training - that have been shown to be effective in promoting active and healthy aging. The objective is to study the molecular and neural mechanisms of these strategies to stimulate brain plasticity and improve brain health and cognitive functioning.
It is a randomized controlled study with three intervention groups - physical, cognitive and
combined - and a control group. The intervention is carried out over 3 months, with a
frequency of 5 weekly sessions of 45 minutes each. Cognitive training is applied through a
computerized program, physical training consists of a walking aerobic program, and combined
training arises from the addition of the two previous ones.
140 participants will undergo an exhaustive pre- and post-intervention evaluation that
includes neuropsychological, neuroimaging, genetic and biochemical analysis before and after
the intervention as well as physical and health status assessment.
The present project aims to examine the independent and combined effects of exercise and
cognitive stimulation in functional and structural brain plasticity, cognitive performance,
emotional state and quality of life, and will determine the demographic and clinical factors
that can modulate neuroplasticity. It will allow us to study the neurophysiological
mechanisms by which the different types of intervention have an effect on the structure and
functioning of the brain and cognition within an omics framework.
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