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NCT03112876 Clinical Trial

Sebum Collection and Skin Barrier Function Analysis

Aging Clinical Trial

— Sebum  

Official title:
Sebum Collection for Analysis and Correlation to Sebum Production, Barrier Function, and With Cutaneous and Internal Inflammatory Disease

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03112876
Other study ID # 605131
Secondary ID
Status Completed
Phase N/A
First received July 10, 2014
Last updated April 7, 2017
Start date June 27, 2014
Est. completion date February 26, 2016

Study information
Verified date April 2017
Source University of California, Davis
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The goal is this study is to evaluate how the skin surface lipid composition is correlated with overall sebum production, barrier function, and inflammatory disease status. We hypothesize that there will be differences in the skin surface composition among subjects of various groups:

1. Young vs older healthy population

2. Atopic dermatitis vs Acne vs Healthy controls

3. Active smokers vs non-smoker controls

Description:

This study will be conducted through the use of painless tapes to collect lipid. These will be applied to the skin and removed. Secondly, the barrier function will be evaluated through the use of non-invasive painless devices that measure sebum, skin water loss, and skin hydration.

Recruitment information / eligibility
Status Completed
Enrollment 41
Est. completion date February 26, 2016
Est. primary completion date February 26, 2016
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 12 Years and older
Eligibility Inclusion Criteria:

- Subjects that are 12 years of age or older

Exclusion Criteria:

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• Skin Surface Lipid Collection and Skin Barrier Function
All five groups will undergo the same study intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.

Locations
Country Name City State
United States UC Davis Department of Dermatology Sacramento California

Sponsors (1)
Lead Sponsor Collaborator
University of California, Davis

Country where clinical trial is conducted

United States, 

References & Publications (2)

Ní Raghallaigh S, Bender K, Lacey N, Brennan L, Powell FC. The fatty acid profile of the skin surface lipid layer in papulopustular rosacea. Br J Dermatol. 2012 Feb;166(2):279-87. doi: 10.1111/j.1365-2133.2011.10662.x. — View Citation

Sakai S, Kikuchi K, Satoh J, Tagami H, Inoue S. Functional properties of the stratum corneum in patients with diabetes mellitus: similarities to senile xerosis. Br J Dermatol. 2005 Aug;153(2):319-23. — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary Lipid Profile-aging The lipid profile of the subject group will be evaluated through the use of painless tapes that will be applied to the skin. 1 day
Primary Lipid Profile-acne The lipid profile of the subject group will be evaluated through the use of painless tapes that will be applied to the skin. 1 day
Primary Lipid Profile-atopic dermatitis The lipid profile of the subject group will be evaluated through the use of painless tapes that will be applied to the skin. 1 day
Primary Lipid Profile-smoking The lipid profile of the subject group will be evaluated through the use of painless tapes that will be applied to the skin. 1 day
Secondary Skin Barrier Function- aging The skin barrier function will be evaluated for this group through the use of non-invasive handheld devices. These devices provide information about sebum secretion rate, skin water loss, and skin hydration. 1 day
Secondary Skin Barrier Function- acne The skin barrier function will be evaluated for this group through the use of non-invasive handheld devices. These devices provide information about sebum secretion rate, skin water loss, and skin hydration. 1 day
Secondary Skin Barrier Function- atopic dermatitis The skin barrier function will be evaluated for this group through the use of non-invasive handheld devices. These devices provide information about sebum secretion rate, skin water loss, and skin hydration. 1 day
Secondary Skin Barrier Function- smoking The skin barrier function will be evaluated for this group through the use of non-invasive handheld devices. These devices provide information about sebum secretion rate, skin water loss, and skin hydration. 1 day
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