Aging Clinical Trial
— TAGEOfficial title:
Effect of Different Strength Training Intensities on Achilles and Patellar Tendon Adaptations With Aging
Verified date | March 2017 |
Source | Université de Technologie de Compiegne |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Tendons are essential structures for transmitting muscle forces to skeletal structures. A stiffer tendon will transmit muscle force faster, and then allow faster movement. Moreover, tendons are a living tissue and respond to mechanical forces by changing their metabolism as well as their structural and mechanical properties. The aim of the present study is to answer essential questions remaining unanswered that are necessary in order to optimize physical activity with ageing in humans, and thus improve quality of life in elderly. The main questions are: What is the minimal training intensity leading to tendon adaptations? What is the time-course of tendon adaptations? Does the same loading protocol lead to similar tendon adaptations for different tendons (Achilles vs Patellar) and does the same training program lead to identical tendon adaptations with age (25yrs vs 75yrs)? To answer these questions, tendon architecture and mechanical properties will be investigated in humans of different age and applying different training intensities. The kinematic of the tendon adaptations due to these different training characteristics will also be investigated. The training protocol will be applied on plantar flexors and knee extensors. MRI and ultrasound techniques as well as the use of ankle and knee ergometers will allow the quantification of possible modifications in tendon architecture and mechanical properties (tendon stiffness and Young's Modulus). This will be assessed in vivo, using ultrasound images to assess tendon displacement during an incremental maximal contraction.
Status | Enrolling by invitation |
Enrollment | 60 |
Est. completion date | July 28, 2017 |
Est. primary completion date | July 28, 2017 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 18 Years to 85 Years |
Eligibility |
Inclusion Criteria: - Males - Age between 18 and 30 years for the young group and between 65 and 85 years for aged group - Physical and mental health, as assessed by clinical investigation - Written informed consent - Willingness to co-operate - Non-smoker - Not addicted to alcohol or drugs - Habitual sedentary/low physical activity levels Exclusion Criteria: - BMI <20 or >28 - Height <155cm, >195cm - Chronic disease with regular clinical treatment - Regular drug intake - Any metabolic or hormonal disorder - Psychiatric conditions - Any blood clotting disorder - Any muscle or bone disease - Metal implants - Any inflammatory disease - Metabolic or hormonal disorder - Participation in sports at competitive rather than at a recreational level - Fractures during the past 6 months - Epilepsy - Back pain - Lower extremity trauma during the past 6 months, or currently experiencing related symptoms, or receiving treatment - Any other condition or history that the investigator considers might increase the risk to the individual or interfere with the evaluation of data |
Country | Name | City | State |
---|---|---|---|
France | Universite de Technologie de Compiegne | Compiegne |
Lead Sponsor | Collaborator |
---|---|
Université de Technologie de Compiegne | Centre Hospitalier Compiègne-Noyon, University of Copenhagen |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Time-course change of tendon size | Tendon size (tendon length and cross sectional area (CSA)) will be assessed using MRI. | T-4weeks (4 weeks before starting intervention), T0 (before starting intervention), T+4weeks (after 4 weeks of intervention), T+8weeks (after 8 weeks of intervention), T+12weeks (at the end of the 12 weeks of intervention) | |
Primary | Time-course change of tendon mechanics (Elastic modulus of the tendon) | Tendon stiffness will be evaluated during voluntary plantar flexion contraction where force and elongation is measured using a force transducer and ultrasound, respectively. Tendon size will be assessed using MRI. Elastic modulus will be calculated based on stiffness and size of tendon. | T-4weeks (4 weeks before starting intervention), T0 (before starting intervention), T+4weeks (after 4 weeks of intervention), T+8weeks (after 8 weeks of intervention), T+12weeks (at the end of the 12 weeks of intervention) | |
Secondary | Time-course change of plantar flexion muscle strength | Plantar flexion muscle strength will be assessed using a specifically designed ankle ergometer under isometric contraction. | T-4weeks (4 weeks before starting intervention), T0 (before starting intervention), T+4weeks (after 4 weeks of intervention), T+8weeks (after 8 weeks of intervention), T+12weeks (at the end of the 12 weeks of intervention) | |
Secondary | Time-course change of calf muscle size | Calf muscle size (i.e. cross sectional area and volume) will be assessed using MRI. | T-4weeks (4 weeks before starting intervention), T0 (before starting intervention), T+4weeks (after 4 weeks of intervention), T+8weeks (after 8 weeks of intervention), T+12weeks (at the end of the 12 weeks of intervention) | |
Secondary | Time-course change of quadriceps muscle strength | Quadriceps muscle strength will be assessed using a specifically designed knee ergometer under isometric contraction. | T-4weeks (4 weeks before starting intervention), T0 (before starting intervention), T+4weeks (after 4 weeks of intervention), T+8weeks (after 8 weeks of intervention), T+12weeks (at the end of the 12 weeks of intervention) | |
Secondary | Time-course change of quadriceps muscle size | Quadriceps muscle size (i.e. cross sectional area and volume) will be assessed using MRI. | T-4weeks (4 weeks before starting intervention), T0 (before starting intervention), T+4weeks (after 4 weeks of intervention), T+8weeks (after 8 weeks of intervention), T+12weeks (at the end of the 12 weeks of intervention) |
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