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Study of Acarbose in Longevity — SAIL  

Aging Clinical Trial

Official title:
Study of Changes in Muscle and Fat Gene Transcription With Acarbose Treatment: a Crossover Study

Clinical Trial Summary

The investigators are studying the effects of acarbose on muscle and adipose gene transcription in older adults.

Clinical Trial Description

Acarbose, an FDA approved drug for the treatment of type 2 diabetes, has known effects on glucose metabolism. Evidence from mice indicates that acarbose may prolong lifespan. In humans, acarbose improves inflammatory markers and reduces cardiovascular events. Consequently, acarbose is of interest in clinical translational aging research since it may influence fundamental processes that contribute to age-related diseases. The study described herein is an exploratory study to examine the effect of acarbose treatment on the biology of aging in humans. Specifically, the investigators plan to study whether treatment with a 10 week course of acarbose will alter the gene expression profile in adipose tissue and muscle in older adults in pathways that are known to be affected by human aging, in a placebo-controlled crossover study. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02953093
Study type Interventional
Source Montefiore Medical Center
Contact
Status Completed
Phase Phase 2
Start date August 30, 2017
Completion date December 26, 2019
View Details
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