Aging Clinical Trial
Official title:
The Northern Ireland Sensory Ageing Study
A visual function focused add-on study to the Northern Ireland Cohort for the Longitudinal
Study of Ageing (NICOLA). There are three key aims:
1. Quantify age-related decline in a variety of visual functions within a populations based
cohort.
2. Explore the mechanisms underlying age-related visual impairments.
3. Investigate how visual function impacts vision related quality of life.
The investigators propose to put together a battery of test to assess different aspects of
visual function and apply them to two groups of participants in order to explore differences
in chronological and physiological aging.
Group 1: 25 participants from each decade from 20-90. Those from 50+ will be recruited from
the NICOLA study and retinal/lens images assessed to confirm normality (drusen <63µm or clear
retina, LOCS III <1). Those younger will be recruited via advertisements in the University
and targeting friends and relatives or NICOLA participants. This will enable the rate of
decline with age to be calculated. Linear, bilinear, and simple nonlinear candidate functions
of parameter vs. age will be applied to determine which best characterises the change.
Group 2: 250 participants NICOLA participants aged 60 will be invited to participate; only
those whose ocular images confirm normality will be included. This will enable mechanisms
underlying individual differences in aging to be investigated. Normal aging will be
determined from group 1 analysis and participants will be able to be categorised as aging
well or aging poorly. Multivariate regression analysis will be used to investigate the
relationship between visual function and lifestyle and environmental factors. Principal
components analysis will be used to look at the relationships between visual parameters.
These participants will also be asked to complete the NEIVFQ-25, to characterise visual
function related quality of life and this will be compared with their measured visual
function.
Visual function parameters measured after protocol refraction will include: Photopic and
mesopic visual acuity and contrast sensitivity using City Occupational acuity-plus
software17, near visual acuity, reading speed and SKILL card18, MAIA microperimetry and cone
dark adaptation.19 Intra-ocular scatter will be assessed using the Oculus C-quant to assess
the extent to which ocular factors are degrading vision.20 Three-point vernier acuity will
also be measured as this is thought to stay stable throughout life.15 Time will be taken to
ensure participants receive sufficient training to produce reliable thresholds.
All study visits will occur at the Welcome-Wolfson Clinic Research Facility.
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