Age Related Changes in Cardiac Physiology as a Predictor of Exercise Tolerance

Aging Clinical Trial

Official title:

Age Related Changes in Cardiac Physiology as a Predictor of Exercise Tolerance

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02779972
• Other study ID #: TASMC-16-UC-0090-16-TLV-CTIL
• Status: Completed
• Phase: N/A
• First received: May 17, 2016
• Last updated: February 14, 2018
• Start date: March 1, 2016
• Est. completion date: February 4, 2018

Study information

• Verified date: February 2018
• Source: Tel-Aviv Sourasky Medical Center
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Aging is associated with numerous changes and adaptations in the cardiovascular system. Vascular and ventricular wall thickness increase, whereas arterial compliance, endothelial function, and ventricular contractility decline. The decline in cardiac function with advancing age is typically seen in parallel to reduced physical activity, and it has been proposed that lifelong exercise training might attenuate the effects of aging on the heart.

The cardiovascular system undergoes several age-related changes. For most healthy older individuals, the heart generally functions well under resting conditions. Structural and physiological changes tend to result in diminished exercise tolerance. However, increasingly it has been shown that even some of these changes are more a result of a sedentary lifestyle than an age-related phenomenon. Most elderly people tend to become less physically active. It is difficult to separate changes intrinsic to the aging process from those arising as a result of a sedentary lifestyle.

Description:

Previous large studies have concluded that resting LV diastolic and systolic function decline with age. The cardiovascular system undergoes several age-related changes. For most healthy older individuals, the heart generally functions well under resting conditions. Structural and physiological changes tend to result in diminished exercise tolerance. However, increasingly it has been shown that even some of these changes are more a result of a sedentary lifestyle than an age-related phenomenon. Most elderly people tend to become less physically active. It is difficult to separate changes intrinsic to the aging process from those arising as a result of a sedentary lifestyle. Studies of aging and physical activity usually compare older athletes with sedentary ones, in which physical activity was not found to attenuate the impact on the aging heart. Thus, the investigators set of to find the difference between hearts of elderly who are physically fit as measured with METS to those who are not. And try and understand the basis of this difference.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 250
• Est. completion date: February 4, 2018
• Est. primary completion date: January 30, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 65 Years and older

Eligibility

Inclusion Criteria:

• All patients above 65 with preserved systolic function and stress echo on a treadmill between 1 Jan 2012 until 31 Dec 2015 in the facility.

Exclusion Criteria:

• Missing complete information used for data collection.

Related Conditions & MeSH terms

• Aging
• Exercise Tolerance

Intervention

Other:
• Echo stress test
Echo stress test

Locations

Country	Name	City	State
Israel	The Tel Aviv Sourasky Medical Center	Tel Aviv

Sponsors (1)

Lead Sponsor	Collaborator
Tel-Aviv Sourasky Medical Center

Country where clinical trial is conducted

Israel, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Cardiac output at maximal stress test	mean cardiac output in liter per minute for each age group	45 minutes