Age-related Changes in Posture Control and Cortex Activity Under a Dynamic Perturbation

Aging Clinical Trial

Official title:

Age-related Changes in Posture Control and Cortex Activity Under a Dynamic Perturbation

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02706496
• Other study ID #: 2014-01-003C
• Status: Completed
• Phase: N/A
• First received: August 25, 2015
• Last updated: March 7, 2016
• Start date: February 2015
• Est. completion date: January 2016

Study information

• Verified date: March 2016
• Source: Taipei Veterans General Hospital, Taiwan
• Contact: n/a
• Is FDA regulated: No
• Health authority: Taiwan: Institutional Review Board
• Study type: Observational

Clinical Trial Summary

With aging, the elderly decreased ability to control postural balance will be accompanied by increased risk of falling (Berg et al, 1992;. Tinetti et al, 1988). According to previous studies, it showed that the elderly over 65 years fall each year probability was 30 %, and it increased with age (Skelton, & Todd, 2004). In view of this, age-related posture control has become important issues of modern preventive medicine and family care.

Description:

Many clinical studies have been developed assessment tools and measurements for clinical staff to provide balanced assessment and intervention. However, the factors of affecting postural control are diverse and complex, not all tools or measurement could effectively detect a risk of falling. In daily living, the postural control involved integration of sensation, biofeedback, movement response, and kinesthetic sense to maintain postural stability, and finally integrated into the neuromuscular system and coordination to help achieve the perfect postural control. Current clinical tools used to assess the fall or research methods to detect the incidence of falls and the lack of effective relevant and contradictory, and it's difficult to effectively evaluate the risk of falls (Gates, et al, 2008).

With the development of postural balance issues associated with aging process in older people, there is no set of standardized equipment, and lack of effective methods for the assessment of normal and older people who fall. In response to these problems, if we can provide a virtual reality interfaces, and with daily living activities as gait, across obstacles activity, sit to stand, will be able to better meet the desire to explore the issue of real significance to enhance researchers for aging, motion analysis, and brain cortex activity mechanism in postural control mechanism.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 37
• Est. completion date: January 2016
• Est. primary completion date: August 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 20 Years to 74 Years

Eligibility

Inclusion Criteria:

• able to walk and climb the stairs without assistive devices,

• could follow the instructions, and

• without well-known balance related diseases or impairments.

Exclusion Criteria:

• With the disease of cardiac and pulmonary system, neuromusculoskeletal system, vision, vestibular apparatus, dizziness experience or cognitive deficit would be excluded the study.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Aging

Locations

Country	Name	City	State
Taiwan	Taipei Veterans General Hospital	Taipei

Sponsors (2)

Lead Sponsor	Collaborator
Taipei Veterans General Hospital, Taiwan	Ministry of Science and Technology, Taiwan

Country where clinical trial is conducted

Taiwan, 

References & Publications (1)

Mierau A, Hülsdünker T, Strüder HK. Changes in cortical activity associated with adaptive behavior during repeated balance perturbation of unpredictable timing. Front Behav Neurosci. 2015 Oct 14;9:272. doi: 10.3389/fnbeh.2015.00272. eCollection 2015. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	center of pressure	0.5m pressure mat (RSscan, Inc., Belgium)	3 minutes for 20 trial	No
Secondary	cortex power spectrum density	32-channel Ag/AgCl Quick-Cap and NuAmps digital amplifier (Neuroscan, El Paso, TX, USA)	3 minutes for 20 trial	No