Neural Correlates of Successful Cognitive Aging

Aging Clinical Trial

Official title:

Neural and Cognitive Changes Associated With Mental Training in Older Adults

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02628548
• Other study ID #: 2015P001851
• Secondary ID: R01AG048351
• Status: Completed
• Phase: N/A
• Start date: January 18, 2016
• Est. completion date: December 31, 2021

Study information

• Verified date: September 2022
• Source: Massachusetts General Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Normal aging is associated with gradual cognitive declines. These mild neurocognitive disturbances affect daily functioning, health status, and quality of life, and likely account for the roughly $2.9 billion lost by the elderly each year to fraud. The goal of this project is to compare two different 8-week training programs to promote successful neural and cognitive aging. Changes in neural structure and cognitive function will be assessed in a cohort of older adults, as well as the long-term stability of these changes over 24 months.

Description:

Normal aging is associated with gradual cognitive declines. These mild neurocognitive disturbances affect daily functioning, health status, and quality of life, and likely account for the roughly $2.9 billion lost by the elderly each year to fraud. People are paying millions out of pocket for cognitive training programs like Lumosity to stave off these declines. These cognitive decreases have been strongly associated with normal age-dependent declines in neural structure and function, including cortical thickness decreases (approximately 0.02 mm per decade) across most of the cortical mantle, as well as decreases in the volume of the hippocampus (approximately 1-2% annually), white matter microstructure, and functional connectivity across the brain. Life expectancy is increasing and so identifying interventions that can be widely implemented and that can slow or reverse normal cognitive decline are clinical and public health priorities. Some training programs can improve cognitive performance in cognitively normal older adults, and gains are maintained post training. The investigators hypothesize that different techniques to boost cognition likely works through different neural mechanisms, and thus may provide different cognitive benefits. The goal of this project is to compare two different 8-week training programs to promote successful neural and cognitive aging. Changes in neural structure and cognitive function will be assessed in a cohort of older adults, as well as the long-term stability of these changes over 24 months.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 175
• Est. completion date: December 31, 2021
• Est. primary completion date: December 31, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 65 Years to 85 Years

Eligibility

Inclusion Criteria:

• 65-80 years of age

• Right-handed

Exclusion Criteria:

1. Lifetime history of schizophrenia or psychosis. Any other Axis I diagnosis in the past 12 months.

2. Subjects must not endorse suicidality, homicidality or self-destructive acts or urges as assessed through a structured clinical interview (SCID)

3. History of seizure or significant head trauma (i.e., extended loss of consciousness, neurological sequelae, or known structural brain lesion).

4. Neurological or medical conditions that would interfere with study procedures or confound results, such as conditions that alter cerebral blood flow or metabolism.

5. Use of psychotropic medications within 12 months prior to study.

6. Daily use of any medication that alters neural metabolism or blood flow.

7. Any concurrent psychotherapy.

8. Having taken no more than 8 meditation classes (or related practices such as yoga, Tai Chi, or Chi Gong) of any kind in the past 6 months, or more than 15 classes in the past 12 months.

9. Pregnancy.

10. Metallic implants or devices contraindicating magnetic resonance imaging.

11. Claustrophobia

Related Conditions & MeSH terms

• Aging

Intervention

Behavioral:
• Cognitive training program
8 week cognitive training program

Locations

Country	Name	City	State
United States	Massachusetts General Hospital	Boston	Massachusetts

Sponsors (3)

Lead Sponsor	Collaborator
Massachusetts General Hospital	National Institute on Aging (NIA), National Institutes of Health (NIH)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in brain structure	Gray matter structure will be assessed before and after the 8 week programs.	8 weeks
Primary	Change in brain activity during a memory test	Brain activity during a memory task will be assessed before and after the 8 week programs.	8 weeks
Secondary	Blood markers	Blood will be collected at baseline, 8 weeks, 12 and 24 months. This will be used to assess changes in various biomarkers that are known to change with aging.	baseline, 8 weeks, 12 and 24 months
Secondary	Change in cognition	Participants will complete a series of memory and attention tests at 6 time-points: baseline, 2 months, 6 months, 12 months 18 months and 24 months.	2 years