Get in Shape in the Team Research: Porukalla Kuntoon Tutkimus

Aging Clinical Trial

— PoKu  

Official title:

Minimum Resistance Training Frequency: Effect on Motivation and Adherence to Train, Overall Health Status and Neuromuscular Performance

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02413112
• Other study ID #: OKM/70/626/2014
• Status: Completed
• Phase: N/A
• First received: February 19, 2015
• Last updated: October 24, 2016
• Start date: January 2015
• Est. completion date: June 2016

Study information

• Verified date: October 2016
• Source: University of Jyvaskyla
• Contact: n/a
• Is FDA regulated: No
• Health authority: Finland: Ethics Committee
• Study type: Interventional

Clinical Trial Summary

It is well accepted that physical activity in the form of resistance training produces a wide variety of neuromuscular-skeletal and health benefits. It is recommended in Finland that older individuals (over 65yr) should perform resistance training twice per week.

Unfortunately, only approx. 5% of older individuals fulfill this recommendation. As Finnish society grows ever older, research should focus on the specific needs of this group and how to improve participation in physical activity, which may ultimately lead to modification of physical activity recommendations - resistance training recommendations are currently the same for young and older adults and do not include specific recommendations on the type of resistance training. However, these recommendations appear to have been developed for "best possible" improvements in maximum strength and muscle size.

Therefore, it is of great importance to identify the number of resistance training sessions per week required to induce improvements in physical fitness, metabolic and bone health status, and importantly the reasons for adherence to/drop-out of resistance training interventions (e.g. motivation to train) in a multi-discipline study. This knowledge would benefit policy makers to update current recommendations for resistance training and to devise strategies to advise realistic targets for resistance training in the older, particularly the less-educated, age group (e.g. TELI-strategy for 2020).

The present study will include a 12-month resistance training intervention with a 12-month follow-up period. Interviews and questionnaires will assess psychological/sociological data and will be collected from both drop-out subjects and those that complete the intervention. Neuromuscular performance and functional capacity will be tested using conventional methods, along with body composition, bone density, and blood tests for metabolic markers of health. Diet and other physical activity will be controlled throughout the intervention period. Measurements are to be performed every 3 months.

It is expected that 5 international peer-reviewed articles will be published in 2016-2017. The data will be presented at international and national conferences in 2015-2017. Finally, results of the entire research will be published in national peer-reviewed journals (e.g. The Age Institute's "Raportteja"). All subjects will be invited to attend an information meeting where group results will be presented and explained.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 105
• Est. completion date: June 2016
• Est. primary completion date: December 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 65 Years to 75 Years

Eligibility

Inclusion Criteria:

• BMI<37

• Does not smoke

• Able to perform all tests and exercises

• Free from episodes during physical activity

Exclusion Criteria:

• BMI>37

• Use of waling aids

• Previous testosterone-altering treatment, e.g. in cancer treatment or hypogonadism

• Serious cardiovascular disease that may lead to complications during exercise

• Use of pharmaceuticals that affect neuromuscular or endocrine systems

• Regular endurance training>3hr per week

• Resistance training experience

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Aging
• Muscle Strength

Intervention

Behavioral:
• Resistance training
Whole-body resistance training in the University gym that is supervised by researchers. Training once per week, Training twice per week, Training thrice per week.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
University of Jyvaskyla

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Force production (Isometric and dynamic maximum strength tests of lower limbs)	Isometric and dynamic maximum strength tests of lower limbs	Change from baseline at 3, 9 and 15 months with data presented at 24 months post-initiation	Yes
Primary	Muscle hypertrophy (Cross-sectional area of quadriceps and triceps surae muscles)	Cross-sectional area of quadriceps and triceps surae muscles	Change from baseline at 3, 9 and 15 months with data presented at 24 months post-initiation	No
Secondary	Body composition (DXA scanning)	for body fat and fat-free mass	Change from baseline at 3, 9 and 15 months with data presented at 24 months post-initiation	Yes
Secondary	Blood count	Basic blood count	Change from baseline at 3, 9 and 15 months with data presented at 24 months post-initiation	Yes
Secondary	Oral glucose tolerance test	Oral glucose tolerance test assessed for glucose and insulin concentrations	Change from baseline at 3, 9 and 15 months with data presented at 24 months post-initiation	Yes
Secondary	Basal hormone concentrations	Basal hormone concentrations from serum	Change from baseline at 3, 9 and 15 months with data presented at 24 months post-initiation	Yes