Optimal Exercise Training and Nutrition Supplementation in Older Men

Aging Clinical Trial

Official title:

Evaluation of the Effects of a Combined Resistance and High-intensity Interval Exercise Training Program, Along With Nutritional Supplementation, on Strength and Physical Function in Older Men

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02281331
• Other study ID #: REB 14-677
• Status: Completed
• Phase: N/A
• Start date: October 1, 2014
• Est. completion date: May 1, 2018

Study information

• Verified date: August 2018
• Source: McMaster University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

As we age we tend to lose muscle mass and strength. These losses contribute to the increased incidence of falls and fractures, metabolic diseases such as type 2 diabetes, loss of independence and reduced quality of life in the elderly. As the number of seniors increases worldwide, it is becoming more and more important to develop strategies to counteract this loss of muscle mass and strength, and promote healthy aging. Fortunately, relatively simple lifestyle modifications are the most potent defense strategies. Exercises such as weight lifting and high-intensity interval exercise (HIIT), which consists of short, repeated bouts of vigorous aerobic exercise interspersed with period of rest, are the most effective in promoting gains in muscle mass and strength. Additionally, components of foods like whey (a protein found in milk), creatine (found in meat), calcium and vitamin D have been shown to independently increase strength. In this study, we are looking to determine how much we can increase muscle strength in older men who are put on an 12 week exercise training program that combines weight lifting and HIIT, and who consume a daily supplement that contains whey protein, creatine, calcium and vitamin D.

Description:

Please see other documentation.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 50
• Est. completion date: May 1, 2018
• Est. primary completion date: December 1, 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 60 Years and older

Eligibility

Inclusion Criteria:

• Sedentary (no participation in a structured exercise training program in past 6 months)

• BMI between 18.5-30.0 kg/m2

• Weight stable for past 6 months

• Normal resting blood pressure, or stage I hypertension

Exclusion Criteria:

• Smoking

• Use of simvastatin or atorvastatin

• Use of non-steroidal anti-inflammatory drugs

• Injuries that prevent safe-participation in an exercise training program

• Prescription blood thinners

• Diabetes or other metabolic disorders

• Cardiac or gastro-intestinal problems

• Infectious disease or cancer

Related Conditions & MeSH terms

• Aging

Intervention

Dietary Supplement:
• Supplement
supplement/placebo plus exercise training

Locations

Country	Name	City	State
Canada	McMaster Univeristy	Hamilton	Ontario

Sponsors (1)

Lead Sponsor	Collaborator
McMaster University

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Muscle mass	DXA, ultrasound	12 weeks
Secondary	Muscle protein synthesis	The incorporation of a stable isotope (deuterium) into muscle tissue will allow for the determination of fractional synthetic rate, which is indicative of muscle protein synthesis.	12 weeks
Secondary	Satellite cell number, density, type I/type II fibre specific satellite cells and myonuclear domain	Histochemical methods will be used to determine how the supplement and training affect muscle growth and regenerative capacity, specifically the behaviour of satellite cells.	12 weeks
Secondary	Glycemic control	Oral glucose tolerance test	12 weeks
Secondary	Cognitive function	Questionnaires and simple computer-based identification, reaction time and memory tasks.	12 weeks