Circulating SIRT6 Expression, Effect on Aging Quality

Aging Clinical Trial

— Sirt6  

Official title:

Circulating Expression Measurement of a Sirtuin Protein Isoform, Sirt6, as an Early Marker of Aging Quality

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01567176
• Other study ID #: 2011.674
• Status: Completed
• Phase: N/A
• Start date: March 2012
• Est. completion date: September 2012

Study information

• Verified date: February 2012
• Source: Hospices Civils de Lyon
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study follows the results of the COMPALICLAMP study (NCT00951392) where the investigators showed a differential expression of sirtuins protein isoforms, Sirt6, in muscle depending on the quality of aging. The investigators seek to confirm this difference in expression level of circulating leukocytes on a larger sample.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: September 2012
• Est. primary completion date: September 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 60 Years and older

Eligibility

Inclusion Criteria:

• Volunteers from the SUVIMAX 2 aging cohort

• Men and women

• Older than 60

• Subject with a global aging quality score of 1 or 3 in the SU.VI.MAX. 2 study

• Covered by Health Insurance System

Exclusion Criteria:

• Subject not in compliance with the recommendation of French National Law

Related Conditions & MeSH terms

• Aging

Intervention

Biological:
• Blood sample
It is a single cross sectional study. All outcome measures will be taken during the investigation with physical examination, questionnaire and a blood sample

Locations

Country	Name	City	State
France	Centre de Recherche en Nutrition Humaine	Pierre Bénite
France	Centre de recherche en nutrition humaine Rhone-Alpes	Pierre Bénite

Sponsors (1)

Lead Sponsor	Collaborator
Hospices Civils de Lyon

Country where clinical trial is conducted

France, 

References & Publications (1)

Bétry C, Meugnier E, Pflieger M, Grenet G, Hercberg S, Galan P, Kesse-Guyot E, Vidal H, Laville M. High expression of CPT1b in skeletal muscle in metabolically healthy older subjects. Diabetes Metab. 2019 Apr;45(2):152-159. doi: 10.1016/j.diabet.2018.01.0 — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Sirt6 expression in circulating leukocytes based on the aging quality	analysis by quantitative RT-PCR method	participants will be followed for the duration of the visit, an expected average of 1 day
Secondary	hand and forearm muscular strength measurement	Hand Grip strength test	participants will be followed for the duration of the visit, an expected average of 1 day
Secondary	Physical examination and anthropometric measurement	Measurement of the weight, height, waist, hips, blood pressure, pulse.	participants will be followed for the duration of the visit, an expected average of 1 day
Secondary	Cognitive assessment	MMSE (Mini Mental State Examination), Five-word test, clock drawing	participants will be followed for the duration of the visit, an expected average of 1 day
Secondary	Physical Activity questionnaire	MAQ (Modifiable Activity Questionnaire)	participants will be followed for the duration of the visit, an expected average of 1 day