Effect of Ageing on Airway Remodeling

Aging Clinical Trial

Official title:

Study of Bronchoalveolar Lung Remodeling in Subjects From 60 Years Free of Progressive Lung Disease: Structure-function Analysis

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT01230879
• Other study ID #: 8268
• Status: Terminated
• Phase: N/A
• Start date: July 15, 2009
• Est. completion date: August 2012

Study information

• Verified date: November 2021
• Source: University Hospital, Montpellier
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of the study is to investigate the relationship between aging and morphological changes in the lung. 120 consecutive healthy volunteers over 60 years will be enrolled for this trial.

Description:

Chest multidetector CT without injection and spirometry data will be obtained from a multicentric sample of individuals between 60 and 95 years of ageExclusion criteria were current smoking, history of smoking within the past 10 years, any known chronic or acute pulmonary disease. Individuals treated with Amiodarone, Bleomycin or methotrexate were excludedOutcome

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 101
• Est. completion date: August 2012
• Est. primary completion date: August 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 60 Years to 95 Years

Eligibility

Inclusion Criteria:

• People from 60 to 95 years old free from chest disease or history of chest disease

Exclusion Criteria:

• Chronic cough

• Dyspnea

• Sinonasal or chest infection during enrollment

• Myocardial infarction.

• Current smoker or past smoker with more than 10 pack year intoxication

Related Conditions & MeSH terms

• Aging
• Airway Remodeling

Intervention

Other:
• EFR and TDM
EFR : Pulmonary function test TDM : tomodensitometry

Locations

Country	Name	City	State
France	University Montpellier Hospital	Montpellier

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Montpellier

Country where clinical trial is conducted

France, 

References & Publications (1)

Bommart S, Marin G, Bourdin A, Molinari N, Klein F, Hayot M, Vachier I, Chanez P, Mercier J, Vernhet-Kovacsik H. Relationship between CT air trapping criteria and lung function in small airway impairment quantification. BMC Pulm Med. 2014 Feb 28;14:29. do — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Bronchial wall thickness	Bronchial wall thickness and remodeling associated with aging	1 day