Aging Clinical Trial
Official title:
Acetaminophen and Impaired Musculoskeletal Adaptations to Exercise Training
The purpose of this study is to determine if taking the pain reliever acetaminophen (ACET) interferes with some of the benefits of weight lifting on muscles and bone density in older men.
The commonly used pain relievers acetaminophen and ibuprofen may impair musculoskeletal
adaptations to progressive resistance exercise training by inhibiting exercise-induced
muscle protein synthesis.
To test the hypothesis that acetaminophen and ibuprofen would diminish training-induced
increases in fat-free mass, untrained men (n=26) aged ≥ 50 years participated in 16 weeks of
high-intensity progressive resistance exercise training and bone-loading exercises and were
randomly assigned to take ACET (1000 mg), ibuprofen (400 mg) or placebo 2 hours before each
exercise session.
The primary outcome was the change in total body fat-free mass measured by dual-energy X-ray
absorptiometry (DXA) at baseline and week 16. Our primary interest was in the comparison of
the acetaminophen and placebo groups.
;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor)
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