Energy Expenditure Responses to Acute Exercise in Older Women (Calorie Expenditure and Exercise)

Aging Clinical Trial

— CEE  

Official title:

Energy Expenditure Responses to Acute Exercise in Older Women

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00988299
• Other study ID #: 09-0864
• Secondary ID: K99AG031297
• Status: Completed
• Phase: N/A
• First received: October 1, 2009
• Last updated: December 2, 2011
• Start date: October 2009
• Est. completion date: December 2011

Study information

• Verified date: December 2011
• Source: Washington University School of Medicine
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Interventional

Clinical Trial Summary

In older, normal-weight women (60-75 yrs, BMI=18-28 kg/m2), an acute bout of higher-intensity (60% of maximum effort) aerobic exercise, in comparison to an isocaloric bout of lower-intensity (45% of maximum effort) exercise (caloric expenditure of 3.5 kcal/kg body weight for both), will result in differential:

1. decline in non-exercise activity calorie expenditure in the subsequent 48 hours after exercise;

2. increase in resting metabolic rate 48 hours after exercise;

3. increase in serum free triiodo-L-thyronine (free T3) concentrations immediately following exercise;

4. decline from pre-exercise in plasma leptin and serum free T3 concentrations 48 hours after exercise.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 26
• Est. completion date: December 2011
• Est. primary completion date: December 2011
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 60 Years to 75 Years

Eligibility

Inclusion Criteria:

1. Women

2. Age 60-75 years

3. normal weight

4. Weight-stable (± 5%) within the previous 3 months

5. Non-smoking for last year

6. Able to provide own transportation to study visits

7. Not currently involved in any other research study

8. Willing and able to participate in all aspects of the trial including research testing

9. Willing to give informed consent to participate

Exclusion Criteria:

1. Self-reported significant cardiovascular disease

2. Other self-reported medical conditions such as diabetes, chronic or recurrent respiratory conditions, active cancer, musculoskeletal disease

3. Medications known to affect exercise performance or metabolism

4. Excess caffeine use (> 500mg/day)

5. Any self-reported contraindications to exercise

6. Clinical depression

7. Abnormal cognitive function -

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Open Label

Related Conditions & MeSH terms

• Aging

Intervention

Other:
• exercise
exercise sessions at 45% and 60% of maximum effort

Locations

Country	Name	City	State
United States	Washington University School of Medicine	St. Louis	Missouri

Sponsors (2)

Lead Sponsor	Collaborator
Washington University School of Medicine	National Institute on Aging (NIA)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	non-exercise activity calorie expenditure		2 days after exercise sessions	No
Secondary	resting metabolic rate		2 days after exercise sessions	No