Relationship Between Physical Activity and Stem Cells in Older Adults

Aging Clinical Trial

Official title:

Relationship Between Physical Activity and Stem Cells in Older Adults

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00690183
• Other study ID #: 0226-08-EP
• Status: Completed
• Start date: June 5, 2008
• Est. completion date: October 1, 2008

Study information

• Verified date: September 2023
• Source: University of Nebraska
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This is a pilot study to develop a collaborative, translational research project investigating whether physical activity may in part exert a positive influence on aging via the mobilization of stem cells. Preliminary data will be collected to explore the relationship between physical activity and stem cell populations found in the blood. The study hypothesis is that stem cell decrease with age, but that persons who are more physically active will have a higher number of stem cells in the blood. The first assessment will include an evaluation of health, physical activity and lifestyle via questionnaires. Height, weight and abdominal girth will be measured, and blood will be drawn for immune and stem cell assessment. Participants will be given a pedometer and accelerometer to wear daily for 7 days. Participants will return for a second visit at which the pedometer and accelerometer will be returned and blood will be drawn. Stem cell and immune assays will be repeated to evaluate the variability of these measures over time. The correlation between stem cell numbers and physical activity will be analyzed.

Description:

Increased numbers of circulating stem cells and physical activity are both associated with improved health in older persons. This pilot study is the initial step in developing a collaborative, translational research project investigating whether physical activity may in part exert a positive influence on aging via the mobilization of stem cells. The specific aim of this pilot project is to collect preliminary data to explore the relationship between physical activity and stem cell populations found in the blood and to determine the variance in the number of circulating stem cells. We hypothesize that stem cell decrease with age, but that persons who are more physically active will have a higher number of stem cells in the blood. A maximum of 40 persons will be recruited to participate. Persons are eligible to participate if they are age 60 or older, haven't been hospitalized recently, do not have an immunologic or blood disease, do not have an infection, and are not undergoing chemotherapy. Subjects will have 2 visits to the UNMC Clinical Research Center (CRC). The first assessment will include an evaluation of health, physical activity and lifestyle via questionnaires. Height, weight and abdominal girth will be measured, and blood will be drawn for immune and stem cell assessment. Subjects will be given a pedometer and accelerometer to wear daily for 7 days. Subjects will return to the CRC for a second visit at which the pedometer and accelerometer will be returned and blood will be drawn. Stem cell and immune assays will be repeated to evaluate the variability of these measures over time. The correlation between stem cell numbers and physical activity will be analyzed. The data will be used to perform sample size calculations for the development of future studies.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 39
• Est. completion date: October 1, 2008
• Est. primary completion date: August 1, 2008
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 60 Years to 105 Years

Eligibility

Inclusion Criteria:

• 60 years of age or older

Exclusion Criteria:

• Hospitalization within 2 months prior

• Immunological disease

• Hematopoietic disease

• No current infection

• No current chemotherapy

Related Conditions & MeSH terms

• Aging

Locations

Country	Name	City	State
United States	University of Nebraska Medical Center	Omaha	Nebraska

Sponsors (1)

Lead Sponsor	Collaborator
University of Nebraska

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	circulating stem cells	Number of circulating stem cells determined by lab	upon enrollment, one week later
Primary	physical activity	physical activity as reported	upon enrollment
Secondary	alcohol consumption	alcohol consumption as reported	upon enrollment
Secondary	smoking history	smoking history as reported	upon enrollment
Secondary	plasma cytokine levels	plasma cytokine levels determined by lab	upon enrollment, one later