Collection of Bone Marrow Aspirate From Volunteer Donors

Aging Clinical Trial

Official title:

Collection of Bone Marrow Aspirate From Volunteer Donors for In Vitro Hematopoietic Research

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00183066
• Other study ID #: AG0046
• Status: Completed
• Phase: N/A
• First received: September 13, 2005
• Last updated: August 3, 2012
• Start date: July 2002
• Est. completion date: August 2012

Study information

• Verified date: August 2012
• Source: National Institutes of Health Clinical Center (CC)
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Federal Government
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to collect bone marrow cells for research purposes.

Description:

This study is designed to provide bone marrow cells for other research studies. The research is being done because there are ongoing experiments in a number of National Institute on Aging (NIA) laboratories that require access to normal human bone marrow aspirate for their studies of the immune system. These studies are done to understand how blood cells are formed and how they function. Samples will be used to study problems such as the immune system in bone marrow failure and related conditions. Cells will be used in laboratory research and may be banked for future laboratory studies

Recruitment information / eligibility

• Status: Completed
• Enrollment: 63
• Est. completion date: August 2012
• Est. primary completion date: August 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Healthy volunteers age 18 and over

Exclusion Criteria:

• Significant abnormalities on health history questionnaire or in the results of blood tests

• Pregnant or nursing mother

• Participation in another research study within the past six weeks that is felt by the Principal Investigator to be incompatible with this study

• Severe infection in the past two months

• Immune disorder, or use of any medication that can alter immune system function

• A medical or mental health finding showing inability to go through the procedure

• Body mass index (BMI) greater than 29%

• Chronic back pain, sciatica, or a compression fracture of the spine

• Positive test results for viral infections: Hepatitis B, Hepatitis C, or HIV (AIDS)

Study Design

Time Perspective: Prospective

Related Conditions & MeSH terms

• Aging

Locations

Country	Name	City	State
United States	NIA Clinical Research Unit located at Harbor Hospital	Baltimore	Maryland

Sponsors (1)

Lead Sponsor	Collaborator
National Institute on Aging (NIA)

Country where clinical trial is conducted

United States, 

References & Publications (3)

Cashman J, Clark-Lewis I, Eaves A, Eaves C. Stromal-derived factor 1 inhibits the cycling of very primitive human hematopoietic cells in vitro and in NOD/SCID mice. Blood. 2002 Feb 1;99(3):792-9. — View Citation

Exley MA, Tahir SM, Cheng O, Shaulov A, Joyce R, Avigan D, Sackstein R, Balk SP. A major fraction of human bone marrow lymphocytes are Th2-like CD1d-reactive T cells that can suppress mixed lymphocyte responses. J Immunol. 2001 Nov 15;167(10):5531-4. — View Citation

Johnson BS, Mueller L, Si J, Collins SJ. The cytokines IL-3 and GM-CSF regulate the transcriptional activity of retinoic acid receptors in different in vitro models of myeloid differentiation. Blood. 2002 Feb 1;99(3):746-53. — View Citation

External Links

•   National Institute on Aging