CALERIE (Tufts) - Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy

Aging Clinical Trial

Official title: Dietary Energy Restriction and Metabolic Aging in Humans

Status Completed

Clinical Trial Summary

This study is one of three CALERIE trials that test the hypothesis that a reduced calorie, nutritionally sound diet increases the length of life and prevents some age-related chronic diseases such as cancer, diabetes, and cardiovascular disease. The three sites that are participating in the CALERIE trial represent a diversity of subject populations and interventional strategies.

Clinical Trial Description

Researchers at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University are enrolling overweight men and women aged 20-42 in a 1-year study to develop an effective calorie restricted regimen that minimizes hunger and prevents weight regain. The study also examines the effects of weight loss on body composition, metabolism and aging. Two different diets containing usual foods and a healthy balance of nutrients will be tested at 2 levels of caloric restriction, 10% and 30% (in other words, 90% or 70% of what one would normally eat). Weight loss is expected for most volunteers participating in this study, but cannot be guaranteed. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind, Primary Purpose: Prevention

Related Conditions & MeSH terms

• Aging

• NCT number: NCT00099099
• Study type: Interventional
• Source: National Institute on Aging (NIA)
• Status: Completed
• Phase: Phase 1
• Start date: March 2002
• Completion date: December 2004