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Tirofiban for the Prevention of Neurological Deterioration in Acute Ischemic Stroke — TREND  

Acute Stroke Clinical Trial

Official title:
Safety and Efficacy of Tirofiban in Preventing Neurological Deterioration of Patients With Acute Ischemic Stroke: A Randomized Controlled Trial

Clinical Trial Summary

Currently, dual antiplatelet therapy with aspirin and clopidogrel (with loading doses) is widely used for patients with acute ischemic stroke. However, immediate, potent and reversible inhibition of platelet aggregation is not possible. Additionally, more than 5% patients have aspirin resistance and more than 15% patients have clopidogrel resistance. Therefore, an intravenously administered GPIIb/IIIa receptor inhibitor (Tirofiban) receptor blocker with fast onset and offset of actions will provide more desired antiplatelet effects in the setting of acute ischemic stroke, especially in patients with high risk of neurological deterioration. This study will measure the anti-platelet effects of Tirofiban in patients with acute ischemic stroke who had high risk of neurological deterioration.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04491695
Study type Interventional
Source Capital Medical University
Contact Qingfeng Ma, M.D.
Phone 010-83199430
Email m.qingfeng@163.com
Status Recruiting
Phase Phase 2/Phase 3
Start date September 12, 2020
Completion date March 31, 2023
View Details
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