Acute Respiratory Failure Clinical Trial
— HPEEPOfficial title:
Invasive Measurement of Positive Tracheal Pressure Generated by High Flow Nasal Oxygen Administration in Critically Ill Patients After Extubation: a Physiologic Study.
NCT number | NCT05467332 |
Other study ID # | HPEEP |
Secondary ID | |
Status | Not yet recruiting |
Phase | |
First received | |
Last updated | |
Start date | April 2023 |
Est. completion date | December 2023 |
High flow nasal cannula administration in critically ill patients is frequently used to improve acute respiratory failure or to prevent respiratory failure after extubation. It acts generating a mild positive pressure in the airways and by reducing respiratory effort of patients. However to the best of our knowledge, no study to date has directly measured the amount of positive pressure generated in the trachea of patients. The primary aim, therefore, of this study measures this positive pressure after extubation in critically ill patients.
Status | Not yet recruiting |
Enrollment | 20 |
Est. completion date | December 2023 |
Est. primary completion date | September 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility | Inclusion Criteria: CRITICALLY ILL PATIENTS AFTER MECHANICAL VENTILATION LASTED AT LEAST 72 HOURS - age 18-80 years Exclusion Criteria: - COPD stage >1 according to GOLD classification - end stage organ disease (liver, kidney, heart, lung) - neuromuscular disease - neoplasm - previous tracheostomy - obesity with BMI > 35 Kg/m2 - non collaborative patient |
Country | Name | City | State |
---|---|---|---|
Italy | Cristian Deana | Udine |
Lead Sponsor | Collaborator |
---|---|
Azienda Sanitaria-Universitaria Integrata di Udine |
Italy,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | HFNC-PEEP | THE LEVEL OF POSITIVE AIRWAY PRESSURE GENERATED BY DIFFERENT FLOW RATES OX OXYGEN WILL BE RECORDED.
FLOW RATE STARTS AT 10 L/MIN AND IT WILL BE INCREASED A 10 L/MIN STEP EVERY 30 MINUTES UNTIL 60 L/MIN. |
3 HOURS | |
Secondary | HFNC-EADI | ELECTRICAL ACTIVITY OF THE DIAPHRAGM WILL BE RECORDED THROUGH A DEDICATED NASOGASTRIC TUBE DURING ALL THE PROCESS.
FLOW RATE STARTS AT 10 L/MIN AND IT WILL BE INCREASED A 10 L/MIN STEP EVERY 30 MINUTES UNTIL 60 L/MIN. |
3 HOURS |
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