Acute Respiratory Failure Clinical Trial
Official title:
Empirical Steroids and/or Antifungals in Immunocompromised Patients With Acute Respiratory Failure From Undetermined Etiology: a Multicenter Double-blind Randomized Controlled Trial
Acute respiratory failure (ARF) is the leading reason of ICU admission in immunocompromised patients. Failure to identify the ARF etiology is associated with increased mechanical ventilation and mortality rates. This was confirmed in the large Efraim 1 study published in 2017, where undetermined ARF etiology affected 609/1611 (38%) patients at day 3, 402 (25%) patients at day 7 and 199 (12.3%) patients overall, and was associated with a case fatality of 55% (vs. 40% in other patients). In lung biopsy/autopsy findings from these patients, invasive fungal infection, steroid-sensitive affections (organized pneumonia, non-infectious interstitial involvement, drug-related pulmonary toxicity…), and lung infiltration by the underlying disease (lymphoma, carcinomatous lymphangitis, systemic vasculitis, connective tissue diseases, etc.) were the leading etiologies. No study has evaluated survival benefits from empirical steroids and/or antifungals in immunocompromised patients with ARF from undetermined etiology. The main objective of this study is to reduce the 90-day mortality in immunocompromised patients with ARF from undetermined etiology at day-3. The intervention would evaluate the impact of steroids ± isavuconazole for 14 days or until ICU discharge.
n/a
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05144633 -
Blue Protocol and Eko Artificial Intelligence Are Best (BEA-BEST)
|
||
Completed |
NCT04534569 -
Expert Panel Statement for the Respiratory Management of COVID-19 Related Acute Respiratory Failure (C-ARF)
|
||
Recruiting |
NCT03021902 -
Nutrition and Exercise in Critical Illness
|
Phase 2 | |
Completed |
NCT02902146 -
Bougie Use in Emergency Airway Management
|
N/A | |
Completed |
NCT02901158 -
Esophageal Manometry in Mechanically Ventilated Patients
|
||
Completed |
NCT02236559 -
High Flow Therapy for the Treatment of Respiratory Failure in the ED
|
N/A | |
Recruiting |
NCT02056093 -
Comparison of Proportional Assist Ventilation And Neurally Adjusted Ventilator Assist
|
N/A | |
Not yet recruiting |
NCT01668368 -
Goal Directed Mechanical Ventilation Aimed at Optimal Lung Compliance
|
N/A | |
Terminated |
NCT01083277 -
Variable Ventilation During Acute Respiratory Failure
|
N/A | |
Completed |
NCT01462279 -
Effect of Thiamine on Oxygen Utilization (VO2) in Critical Illness
|
N/A | |
Completed |
NCT01114022 -
Prevention Inhalation of Bacterial by Using Endotracheal Tube Balloon Polyvinyl Chloride or Polyurethane
|
N/A | |
Active, not recruiting |
NCT01058421 -
Treatment of Critical Illness Polyneuromyopathy
|
Phase 2 | |
Completed |
NCT00252616 -
Timing of Target Enteral Feeding in the Mechanically Ventilated Patient
|
Phase 2/Phase 3 | |
Recruiting |
NCT04098094 -
Outcomes of RV Dysfunction in Acute Exacerbation of Chronic Respiratory Diseases
|
||
Recruiting |
NCT06051292 -
Decremental Esophageal Catheter Filling Volume Titration For Transpulmonary Pressure Measurement
|
N/A | |
Completed |
NCT04601090 -
Survival Rates and Longterm Outcomes After COVID-19
|
||
Recruiting |
NCT05423301 -
Global Physiotherapy in ICU Patients With High Risk Extubation Failure
|
N/A | |
Completed |
NCT02447692 -
Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: The PROMIZING Study
|
N/A | |
Completed |
NCT04016480 -
HFNC During Bronchoscopy for Bronchoalveolar Lavage
|
N/A | |
Completed |
NCT04507425 -
High Flow Nasal Cannula With Noninvasive Ventilation
|
N/A |