Hypercapnic Acute Respiratory Failure in the ICU : the YETI Study

Acute Respiratory Failure Clinical Trial

— YETI  

Official title:

Hypercapnic Acute Respiratory Failure in the ICU : the YETI Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04304339
• Other study ID #: YETI
• Status: Completed
• Start date: December 14, 2021
• Est. completion date: July 13, 2022

Study information

• Verified date: March 2023
• Source: French Society for Intensive Care
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Hypercapnia is a frequent clinical situation defined as an elevation of the partial pressure of carbon dioxide (PaCO2) above 45 mmHg. Several physiopathological parameters such as respiratory minute volume, dead space volume or CO2 production influence the PaCO2. Therefore, hypercapnia can affect the time of various diseases. Available epidemiological data regarding hypercapnia are from studies investigating the efficacy of non-invasive ventilation (NIV), with different population cohorts. However, their interpretation must be cautious given the heterogeneity in patient case-mix and results. Then, whether hypercapnia is a common reason for intensive care unit (ICU) admission, epidemiological data is scarce and heterogeneous. The aim of this study is to investigate the epidemiological, clinical determinants and outcomes of patients admitted to ICU with hypercapnic respiratory failure.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 862
• Est. completion date: July 13, 2022
• Est. primary completion date: July 13, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• patients =18 years old presenting with at least of the following items :

1. respiratory rate = 25/min,

2. paradoxical motion of the abdomen,

3. intercostal retraction AND

• a PaCO2 > 45 cm H20 before ICU admission or within the 12 hours following ICU admission.

Exclusion Criteria:

• Refusal to give informed consent,
• pregnancy,
• < 18 years patient,
• dying patient

Related Conditions & MeSH terms

• Acute Respiratory Failure
• Hypercapnia
• Intensive Care Unit Syndrome
• Respiratory Distress Syndrome
• Respiratory Insufficiency

Intervention

Other:
• Hypercapnic respiratory failure
Patients with hypercapnic respiratory failure will be followed without any additional intervention

Locations

Country	Name	City	State
France	CHU Nantes	Nantes
France	CHU Toulouse	Toulouse
France	CH Andre Migniot	Versailles	A

Sponsors (1)

Lead Sponsor	Collaborator
French Society for Intensive Care

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Prevalence of hypercapnic acute respiratory failure in ICU	Number of patients with hypercapnic acute respiratory failure in ICU related to number of patients admitted in the ICU during study period	Intensive Care Unit length stay (Usually 7 days)