Clinical Trials Logo
  1. Home
  2. Acute Respiratory Failure
  3. NCT03826797
  4. Details
NCT03826797 Clinical Trial

Correlation Between Trans Esophageal Pressure and Non-invasive Respiratory Support Failure in Patients With Acute Hypoxic Respiratory Failure

Acute Respiratory Failure Clinical Trial

— TEMPO  

Official title:
Correlation Between Trans Esophageal Pressure and Non-invasive Respiratory Support Failure in Patients With Acute Hypoxic Respiratory Failure

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT03826797
Other study ID # UModenaReggio 266/16
Secondary ID 266/16
Status Recruiting
Phase
First received
Last updated
Start date October 16, 2016
Est. completion date December 31, 2027

Study information
Verified date March 2023
Source University of Modena and Reggio Emilia
Contact Alessandro Marchioni, MD, PhD
Phone 00390594225859
Email marchioni.alessandro@unimore.it
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

This study aims at assessing the correlation between trans esophageal pressure and related respiratory mechanics (including, among others, nasal pressure-Pnose) and non-invasive respiratory support failure in patients with acute hypoxic respiratory failure of different etiology (including COVID-19).

Recruitment information / eligibility
Status Recruiting
Enrollment 300
Est. completion date December 31, 2027
Est. primary completion date February 28, 2024
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Age >18 years - Acute hypoxic respiratory failure (P/F < 200) Exclusion Criteria: - Acute pulmonary edema - Chest wall deformities - Immediate need for Mechanical Ventilation - Pregnancy - Hypercapnic RF

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Italy University Hospital of Modena Policlinico Modena

Sponsors (1)
Lead Sponsor Collaborator
University of Modena and Reggio Emilia

Country where clinical trial is conducted

Italy, 

Outcome
Type Measure Description Time frame Safety issue
Primary Esophageal pressure impact on non invasive respiratory support (NRS) failure Correlation between esophageal pressure values within 24 hours from NRS start and NRS failure 24 hours
Secondary Transpulmonary pressure impact on NRS failure Correlation between transpulmonary pressure values within 24 hours from NRS start and NRS failure 24 hours
Secondary Dynamic compliance impact on NRS failure Correlation between dynamic compliance values within 24 hours from NRS start and NRS failure 24 hours
Secondary Dynamic mechanical power impact on NRS failure Correlation between dynamic mechanical power within 24 hours from NRS start and NRS failure 24 hours
Secondary Correlation between nasal pressure (Pnose) and esophageal pressure Correlation between nasal pressure (Pnose) and esophageal pressure 24 hours
Secondary Pnose impact on NRS failure Correlation between Pnose within 24 hours from NRS start and NRS failure 24 hours
See also
  Status Clinical Trial Phase
Recruiting NCT05144633 - Blue Protocol and Eko Artificial Intelligence Are Best (BEA-BEST)
Completed NCT04534569 - Expert Panel Statement for the Respiratory Management of COVID-19 Related Acute Respiratory Failure (C-ARF)
Recruiting NCT03021902 - Nutrition and Exercise in Critical Illness Phase 2
Completed NCT02902146 - Bougie Use in Emergency Airway Management N/A
Completed NCT02901158 - Esophageal Manometry in Mechanically Ventilated Patients
Completed NCT02236559 - High Flow Therapy for the Treatment of Respiratory Failure in the ED N/A
Recruiting NCT02056093 - Comparison of Proportional Assist Ventilation And Neurally Adjusted Ventilator Assist N/A
Terminated NCT01083277 - Variable Ventilation During Acute Respiratory Failure N/A
Not yet recruiting NCT01668368 - Goal Directed Mechanical Ventilation Aimed at Optimal Lung Compliance N/A
Completed NCT01462279 - Effect of Thiamine on Oxygen Utilization (VO2) in Critical Illness N/A
Completed NCT01114022 - Prevention Inhalation of Bacterial by Using Endotracheal Tube Balloon Polyvinyl Chloride or Polyurethane N/A
Active, not recruiting NCT01058421 - Treatment of Critical Illness Polyneuromyopathy Phase 2
Completed NCT00252616 - Timing of Target Enteral Feeding in the Mechanically Ventilated Patient Phase 2/Phase 3
Recruiting NCT04098094 - Outcomes of RV Dysfunction in Acute Exacerbation of Chronic Respiratory Diseases
Recruiting NCT06051292 - Decremental Esophageal Catheter Filling Volume Titration For Transpulmonary Pressure Measurement N/A
Completed NCT04601090 - Survival Rates and Longterm Outcomes After COVID-19
Recruiting NCT05423301 - Global Physiotherapy in ICU Patients With High Risk Extubation Failure N/A
Completed NCT02447692 - Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: The PROMIZING Study N/A
Completed NCT04016480 - HFNC During Bronchoscopy for Bronchoalveolar Lavage N/A
Completed NCT04507425 - High Flow Nasal Cannula With Noninvasive Ventilation N/A