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Initial Ventilation Strategy for Adult Immunocompromised Patients With Acute Respiratory Failure

Acute Respiratory Failure Clinical Trial

Official title:
Initial Ventilation Strategy for Adult Immunocompromised Patients With Acute Respiratory Failure

Clinical Trial Summary

VENIM is a multicenter, open-label, parallel-group randomized controlled trial of studying the initial ventilation strategy for adult immunocompromised patients with acute respiratory failure.

Clinical Trial Description

The VENIM is a multicenter randomized controlled trial (RCT) comparing the effects of NIV compared with IMV in adult immunocompromised patients with moderate to severe acute respiratory failure (ARF). Patients who meet the indications for both ventilatory supports will be included. The intervention will consist of randomly allocation, treatment with NIV or IMV, concomitant medication. Primary outcome is 30-day hospital mortality. Secondary outcomes include in-hospital mortality, length of stay in hospital, improvement of oxygenation, nosocomial infections, seven-day organ failure, adverse events of intervention, et al. Subgroups with different disease severity, causes of immunodeficiency and types of ARF will also be analyzed. ;

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02983851
Study type Interventional
Source Peking Union Medical College Hospital
Contact Yi Li, M.D.
Phone 13693109826
Email billliyi@126.com
Status Not yet recruiting
Phase N/A
Start date December 2016
Completion date December 2018
View Details
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