Acute Respiratory Failure Clinical Trial
Official title:
Impact of Nasal High-flow vs Venturi Mask Oxygen Therapy on Weaning Outcome: a Multicenter, Randomized, Controlled Trial
The purpose of this study is to determine whether, as compared with the Venturi mask, a nasal, high-flow oxygenation device (Optiflow) may reduce the extubation failure rate in patients needing oxygen therapy after extubation.
This study compares the effects of two devices for oxygen therapy, the nasal, high-flow
(Optiflow, intervention) and the Venturi mask (control), on the outcome of extubation.
Available data suggest that Optiflow can improve oxygenation and patient's comfort in
critically ill patients after extubation. The study hypothesis is that Optiflow may reduce
the extubation failure rate in these patients.
In the intervention group, patients fulfilling inclusion criteria and not presenting any of
the exclusion criteria will receive high-flow oxygen through nasal cannula (Optiflow, Fisher
& Paykel Healthcare Ltd., New Zealand) after extubation. The oxygen concentration (FiO2) will
be set to reach an oxygenation target similar to control patients (see below), while the gas
flow rate will be set at 50 L/min.
In the control group, patients fulfilling inclusion criteria and not presenting any of the
exclusion criteria will receive oxygen through a standard Venturi mask after extubation. The
FiO2 will be set to obtain a arterial oxygen saturation (SpO2) between 92% and 98% (or
between 88% and 95% in hypercapnic patients). Further FiO2 modifications will be performed by
the attending physicians to meet the oxygenation target.
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