Third International Study on Mechanical Ventilation

Acute Respiratory Failure Clinical Trial

— ISMV  

Official title:

Third Prospective, Observational, International, Multicenter Study on Mechanical Ventilation

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01093482
• Other study ID #: ISMV-2010
• Status: Completed
• Phase: N/A
• First received: March 23, 2010
• Last updated: February 1, 2018
• Start date: April 2010
• Est. completion date: September 2010

Study information

• Verified date: February 2018
• Source: Hospital Universitario Getafe
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The objective of this study is to obtain a better understanding of the spectrum of use of mechanical ventilation in intensive care units:

1. Main analysis: To know the all-cause mortality rate in mechanically ventilated patients

2. Secondary analyses:

• To know the current status of mechanical ventilation in the intensive care unit and determine the number and percentage of patients who are admitted to an intensive care unit and require mechanical ventilation.

• To compare the results with prior data collected in previous observational studies (1998 and 2004)

• Non-invasive positive pressure ventilation

• Weaning

• Use of adjuvant therapies as steroids or selective digestive decontamination

• Sedation including prevalence of delirium in mechanically ventilated patients

• Prediction of the duration of mechanical ventilation

• Other

Description:

Mechanical ventilation is commonly used in patients admitted to intensive care units. Clinical studies have investigated some of the aspects associated with its utilization, and have contributed to improve the knowledge and management of patients with acute respiratory failure. In 1998 the invesgtigators conducted the first international study on mechanical ventilation, including 5183 patients who were mechanically ventilated longer than 12 hours (Esteban A. JAMA 2002). Six years later, the investigators carried out the second international study on mechanical ventilation including 4968 patients. These studies allowed us to analyze the evolution of mechanical ventilation and to judge the concordance of practice with results of randomized trials (Esteban A. Am J Respir Crit Care 2008). The main finding of this study was the high degree of concordance between observed changes in mechanical ventilation practice and changes predicted from reports of randomized controlled trials. However, despite apparently beneficial changes in ventilatory practice, the investigators were not able to detect significant differences in clinical outcomes over this time period. Our results serve as an updated benchmark on the usual care and outcomes of mechanically ventilated patients in a 'real-world' setting.

The investigators now propose to conduct a third international study of mechanical ventilation, 6 years after the 2nd study and 12 years after the original. This will again be a prospective, multicenter single-cohort study, which will enroll consecutive patients who have received mechanical ventilation for at least 12 hours during a 1-month period, and will follow each patient for the duration of mechanical ventilation, up to 28 days. With this 3rd study the investigators aim: 1) to determine if the observed changes that the investigators reported previously are maintained over time; 2) to evaluate if the changes implemented have impacted outcomes; 3) to analyze some aspects related to withdrawal of mechanical ventilation; and implementation non-invasive positive pressure ventilation; and 4) to evaluate what differences may occur between geographical areas.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 8151
• Est. completion date: September 2010
• Est. primary completion date: July 2010
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patients who are admitted to the intensive care unit and require invasive mechanical ventilation (endotracheal tube or tracheostomy) for more than 12 hours.

• Patients who are admitted to the intensive care unit and require non-invasive mechanical ventilation (BIPAP or CPAP with nasal or facial mask) for more than 1 hour.

Exclusion Criteria:

• Patients less than 18 years old

Related Conditions & MeSH terms

• Acute Respiratory Failure
• Respiratory Distress Syndrome, Adult
• Respiratory Insufficiency

Locations

Country	Name	City	State
Argentina	Hospital Naval Puerto Belgrano	Bahía Blanca
Argentina	Clinica Bazterrica	Buenos Aires
Argentina	Clínica Santa Isabel	Buenos Aires
Argentina	Hospital A. Posadas	Buenos Aires
Argentina	Hospital Churruca-Visca	Buenos Aires
Argentina	Hospital Español	Buenos Aires
Argentina	Hospital General de Agudos Bernardino Rivadavia	Buenos Aires
Argentina	Hospital General de Agudos Dalmacio Vélez Sársfield	Buenos Aires
Argentina	Hospital General de Agudos donación Francisco Santojanni	Buenos Aires
Argentina	Hospital General de Agudos Juan A. Fernandez	Buenos Aires
Argentina	Hospital General de Agudos P. Piñeiro	Buenos Aires
Argentina	Hospital Municipal Coronel Suárez	Buenos Aires
Argentina	Hospital Universitario, Universidad Abierta Interamericana	Buenos Aires
Argentina	Sanatorio Anchorena	Buenos Aires
Argentina	Sanatorio de la Trinidad	Buenos Aires
Argentina	Sanatorio de los Arcos	Buenos Aires
Argentina	Sanatorio Dr. Julio Méndez	Buenos Aires
Argentina	Sanatorio Mater Dei	Buenos Aires
Argentina	Sanatorio Otamendi y Miroli	Buenos Aires
Argentina	Hospital Regional de Comodoro Rivadavia	Comodoro Rivadavia
Argentina	Hospital Tránsito Cáceres de Allende	Córdoba
Argentina	Sanatorio Allende	Córdoba
Argentina	Hospital Zonal Francisco López Lima	General Roca
Argentina	Hospital Interzonal General de Agudo Profesor Dr .Luis Guemes	Haedo
Argentina	Hospital Interzonal de Agudos San Martin	La Plata
Argentina	Hospital Privado de Comunidad	Mar del Plata
Argentina	Hospital Central	Mendoza
Argentina	Hospital Lagomaggiore	Mendoza
Argentina	Hospital Universitario Austral	Pilar
Argentina	Policlínico Atlántico del Sur	Río Gallegos
Argentina	Hospital Regional Rio Grande	Río Grande
Argentina	Hospital Provincial del Centenario	Rosario
Argentina	Sanatorio de la Trinidad	San Isidro
Argentina	Sanatorio Las Lomas	San Isidro
Argentina	Hospital de San Luis	San Luis
Argentina	Hospital Pablo Soria	San Salvador de Jujuy
Argentina	Sanatorio Nuestra Señora del Rosario	San Salvador de Jujuy
Argentina	Sanatorio Juncal	Temperley
Argentina	Clínica Olivos	Vicente López
Argentina	Clínica Privada de Especialidades de Villa María	Villa María
Australia	Calvary Wakefield Hospital	Adelaide
Australia	Flinders Medical Center	Adelaide
Australia	Ballarat Health Services	Ballarat
Australia	Bendigo Hospital	Bendigo
Australia	Mater Health Services	Brisbane
Australia	Canberra Hospital	Canberra
Australia	Royal Darwin Hospital	Darwin
Australia	Barwon Health, Geelong Hospital	Geelong
Australia	Royal Hobart Hospital	Hobart
Australia	Liverpool Hospital	Liverpool
Australia	Alfred Hospital	Melbourne
Australia	Royal Melbourne Hospital	Melbourne
Australia	St Vincent's Hospital	Melbourne
Australia	The Northern Hospital	Melbourne
Australia	The Western Hospital	Melbourne
Australia	Central Gippsland Hospital	Sale
Australia	Concord Hospital	Sidney
Australia	Nepean Hospital	Sidney
Australia	St George Hospital	Sidney
Australia	St Vincent's Hospital	Sidney
Bolivia	Hospital Obrero No.1	La Paz
Bolivia	Instituto Gastroenterológico	La Paz
Brazil	Hospital da Baleia	Belo Horizonte
Brazil	Hospital da Polícia Militar	Belo Horizonte
Brazil	Hospital de Pronto Socorro Risoleta Tolentino Neves	Belo Horizonte
Brazil	Hospital Dia e Maternidade Unimed-BH	Belo Horizonte
Brazil	Hospital Felício Rocho	Belo Horizonte
Brazil	Hospital Júlia Kubitschek	Belo Horizonte
Brazil	Hospital Luxemburgo	Belo Horizonte
Brazil	Hospital Madre Teresa	Belo Horizonte
Brazil	Hospital Nossa Senhora Aparecida	Belo Horizonte
Brazil	Hospital São Francisco-Setimig	Belo Horizonte
Brazil	Hospital Universitario Sao Jose	Belo Horizonte
Brazil	Hospital Vera Cruz	Belo Horizonte
Brazil	Hospital Vila da Serra	Belo Horizonte
Brazil	Hospital Santa Rita	Contagem
Brazil	Hospital São João de Deus	Divinópolis
Brazil	Hospital de Messejana	Fortaleza
Brazil	Hospital Universitário Walter Cantídio	Fortaleza
Brazil	Hospital Universitário da Universidade Federal de Juiz de Fora	Juiz de Fora
Brazil	Hospital Vaz Monteiro	Lavras
Brazil	Santa Casa de Misericórdia de Ouro Preto	Ouro Preto
Brazil	Hospital Arnaldo Gavazza Filho	Ponte Nova
Brazil	Hospital Nossa Senhora das Graças	Sete Lagoas
Brazil	Hospital São João Batista	Viçosa
Canada	William Osler Health Science Centre	Brampton	Ontario
Canada	Queen Elizabeth II Health Sciences Centre	Halifax	Nova Scotia
Canada	Saint Joseph Hospital	Hamilton	Ontario
Canada	Ottawa Hospital	Ottawa	Ontario
Canada	Mount Sinai Hospital	Toronto	Ontario
Canada	Saint Michael´s Hospital	Toronto	Ontario
Canada	Sunnybrook Health Science Centre	Toronto	Ontario
Canada	Toronto General Hospital	Toronto	Ontario
Canada	Toronto Hospital Western Division	Toronto	Ontario
Canada	Toronto Western Hospital	Toronto	Ontario
Chile	Hospital de Copiapo	Copiapo
Chile	Hospital de Coquimbo	Coquimbo
Chile	Instituto Nacional del Tórax	Santiago
China	Beijing Chaoyang Hospital	Beijing
China	Beijing Hospital	Beijing
China	Beijing Huaxin Hospital	Beijing
China	Beijing TCM Hospital	Beijing
China	Beijing Tongren Hospital	Beijing
China	Peking Union Medical College Hospital	Beijing
China	Peking University 3rd Hospital	Beijing
China	PLA 304 Hospital	Beijing
China	PLA General Hospital	Beijing
China	PLA Navy General Hospital	Beijing
China	Sino-Japanese Friendship Hospital	Beijing
China	Jilin University 2nd Hospital	Changchun
China	Sichuan Provincial Hospital	Chengdu
China	West China Hospital	Chengdu
China	Chongqing Medical University 1st Hospital	Chongqing
China	Daping Hospital	Chongqing
China	Yunnan Chuxiong People's Hospital	Chuxiong
China	Dalian Medical University 1st Hospital	Dalian
China	Guangdong General Hospital	Guangdong
China	Sun Yet-Sen University 6th Hospital	Guangzhou
China	Hainan Medical College Hospital	Haikou
China	Hainan Provincial People's Hospital	Haikou
China	Zhejiang Haining People's Hospital	Haining
China	Zhejiang Tongde Hospital	Hangzhou
China	North District Hospital	Hong Kong
China	Pamela Youde Nethersole Eastern Hospital	Hong Kong
China	Prince Margaret Hospital	Hong Kong
China	Prince Of Wales Hospital	Hong Kong
China	Queen Elizabeth Hospital	Hong Kong
China	Kunming City 3rd People's Hospital	Kunming
China	Kunming Medical College 1st Hospital	Kunming
China	Nanchang University 2nd Hospital	Nanchang
China	Southeast University Zhongda Hospital	Nanjing
China	Nantong 1st People's Hospital	Nantong
China	Hebei Medical University 4th Hospital	Shijiazhuang
China	Suzhou University 1st Hospital	Suzhou
China	Fengrun District People's Hospital	Tangshan
China	Wuhan University Zhongnan Hospital	Wuhan
China	Wuxi Municipal People's Hospital	Wuxi
China	Xi'an Jiaotong University 1st Hospital	Xi'an
China	Xuzhou Central Hospital	Xuzhou
China	Yantai Yuhuangding Hospital	Yantai
Colombia	Clínica General del Norte	Barranquilla
Colombia	Clínica Fundadores	Bogotá
Colombia	Clínica Shaio	Bogotá
Colombia	Grupo Cimca Hospital de San José (medical ICU)	Bogotá
Colombia	Grupo Cimca Hospital de Suba	Bogotá
Colombia	Grupo Cimca Hospital San José	Bogotá
Colombia	Hospital Santa Clara	Bogotá
Colombia	Fundación cardiovascular colombiana	Bucaramanga
Colombia	Centro Medico Imbanaco	Cali
Colombia	Clínica Fundación Valle Lili	Cali
Colombia	Nuevo Hospital Bocagrande	Cartagena de Indias
Colombia	Hospital Federico Lleras Acosta	Ibague
Colombia	Hospital San Rafael	Itagui
Colombia	Clínica Cardiovascular	Medellín
Colombia	Clínica Las Américas	Medellín
Colombia	Clínica Medellín & Universidad Pontificia Bolivariana	Medellín
Colombia	Clinica Universitaria Bolivariana	Medellín
Colombia	Corbic	Medellín
Colombia	Hospital General de Medellín	Medellín
Denmark	Holbak	Holbaek
Denmark	Koge	Koge
Denmark	Naestved	Naestved
Denmark	Nykobing Falster	Nykobing Falster
Denmark	Roskilde	Roskilde
Denmark	Slagelse	Slagelse
Ecuador	Hospital José Carrasco Arteaga	Cuenca
Ecuador	Hospital Luis Vernaza	Guayaquil
Ecuador	Hospital San Vicente de Paul	Ibarra
Ecuador	Hospital Carlos Andrade Marín	Quito
Ecuador	Hospital de la Policía	Quito
Ecuador	Hospital de los Valles	Quito
Ecuador	Hospital de SOLCA (ICU medical surgical & ICU medical)	Quito
Ecuador	Hospital Enrique Garcés	Quito
Ecuador	Hospital Eugenio Espejo	Quito
Ecuador	Hospital General de las Fuerzas Armadas	Quito
Ecuador	Hospital Metropolitano	Quito
Ecuador	Hospital Pablo Arturo Suárez	Quito
Egypt	Cairo University Hospitals	Cairo
France	Hôpital d'Armentières	Armentieres
France	Centre Hospitalier de Châlons en Champagne	Châlons en Champagne
France	CHU Henri Mondor	Creteil
France	CHU d'Angers	d'Angers
France	CHU De Grenoble	Grenoble
France	Centre Hospitalier Du Mans	Le Mans
France	Hôpital Édouard Herriot	Lyon
France	Centre Hospitalier De Montauban	Montauban
France	Centre Hospitalier De Roanne	Roanne
France	CHU Charles Nicolle	Rouen
France	Centre Hospitalier De Saint-Malo	Saint-Malo
Germany	Katholische Stiftung Marienhospital Aachen	Aachen
Germany	Universitaetsklinikum Aachen	Aachen
Germany	St. Nikolaus-Stiftshospital GmbH	Andernach
Germany	Klinikum Bad Salzungen GmbH	Bad Salzungen
Germany	Ermstalklinik Bad Urach	Bad Urach
Germany	Charité Universitaetsklinikum (ICU medical-surgical & ICU other)	Berlin
Germany	Lungenklinik Heckeshorn	Berlin
Germany	Vivantes Krankenhaus am Urban	Berlin-Kreuzberg
Germany	Evangelisches Waldkrankenhaus Bad Godesberg gGmbH	Bonn
Germany	Universitaetsklinikum Bonn (ICU medical-surgical & ICU surgical)	Bonn
Germany	Carl-Thiem-Klinikum Cottbus gGmbH	Cottbus
Germany	Evangelisches Krankenhaus Elisabethenstift gGmbH	Darmstadt
Germany	Universitaetsklinikum Carl Gustav Carus	Dresden
Germany	Evangelisches Diakoniekrankenhaus	Freiburg
Germany	Universitaetsklinikum der Georg-August-Universitaet	Gotinga
Germany	Staedtisches Krankenhaus Martha-Maria Halle-Doelau gGmbH	Halle
Germany	Allgemeines Krankenhaus Harburg	Hamburg
Germany	Medizinische Hochschule Hannover	Hannover
Germany	Staedtisches Klinikum Lueneburg	Lueneburg
Germany	Universitaetsklinikum	Magdeburg
Germany	Hufeland Klinikum GmbH	Mühlhausen
Germany	Dietrich-Bonhoeffer Klinikum Neubrandenburg	Neubrandenburg
Germany	Klinikum der Universitaet Regensburg	Regensburg
Germany	Ermstalklinik Staedtisches Krankenhaus Sindelfingen	Sindelfingen
Germany	Bundeswehrkrankenhaus Ulm	Ulm
Germany	Universitaetsklinikum der Martin-Luther-Universitaet Halle-Wittenberg	Wittenberg
Germany	Staedtisches Klinikum Wolfenbuttel	Wolfenbuttel
Germany	Georgius-Agricola-Klinikum Zeitz	Zeitz
Greece	Agios Pavlos General Hospital	Thessaloniki
Greece	Ahepa Hospital	Thessaloniki
Greece	Gennimata Hospital	Thessaloniki
Greece	Papageorgiou Hospital	Thessaloniki
Hungary	Kenezy Hospital	Debrecen
Hungary	University of Szeged (Four ICU)	Szeged
India	Kalinga Hospital	Bhubaneswar
India	Calcutta Medical Research Institute	Calcutta
India	Apollo Hospitals	Chennai
India	Artemis Health Institute	Gurgaon
India	CHL Apollo Hospital	Indore
India	Tata Main Hospital	Jamshedpur
India	AMRI Hospitals Kolkata	Kolkata
India	Calcutta medical research institute (CMRI)	Kolkata
India	Kasturba Medical College	Manipal City
India	Bombay Hospital Institute of Medical Sciences	Mumbai
India	Hinduja Hospital	Mumbai
India	Saifee Hospital	Mumbai
India	Tata Memorial Hospital	Mumbai
India	Ruby Hall Clinic	Pune
India	CARE Hospitals	Surat
India	Spandan Multispeciality Hospital	Vadodara
Italy	Ospedale Policlinico, Università Di Bari	Bari
Italy	Policlinico Universitario "S. Orsola-Malpighi"	Bologna
Italy	Ospedale "San Giovanni Di Dio"	Firenze
Italy	Ospedale "Santa Maria Annunziata"	Firenze
Italy	Fondazione IRCCS "Cà Grande" Ospedale Maggiore Policlinico, Università Di Milano	Milano
Italy	Ospedale "San Gerardo", Università Di Milano Bicocca	Monza
Italy	Ospedale "V. Monaldi"	Napoli
Italy	Ospedale Policlinico "Federico II", Università Di Napoli	Napoli
Italy	Ospedale Maggiore Della Carità, Università Del Piemonte Orientale "Amedeo Avogadro"	Novara
Italy	Ospedale "Arnas Civico, Di Cristina, Benfratelli"	Palermo
Italy	Policlinico "P. Giaccone", Università Di Palermo	Palermo
Italy	Fondazione IRCCS Policlinico "S. Matteo", Università Di Pavia (ICU 1 & ICU 2)	Pavia
Italy	Policlinico "Agostino Gemelli", Università Cattolica Del Sacro Cuore	Roma
Italy	Policlinico "Umberto I", Università La Sapienza	Roma
Italy	Ospedale "San Giovanni Battista - Molinette", Università Di Torino	Torino
Japan	Tokyo Women's Medical University	Tokyo
Korea, Republic of	Hospital Korea University of Ansan	Ansan
Korea, Republic of	Hallym University Medical Center	Anyang
Korea, Republic of	Hospital Chungbuk National University	Cheongju
Korea, Republic of	Hospital Chuncheon Sacred Heart Hospital, Hallym University Medical Center	Chuncheon
Korea, Republic of	Hospital Catholic University of Daegu	Daegu
Korea, Republic of	Hospital Dongguk University of Gyeongju	Gyeongju
Korea, Republic of	Asan Medical Center, University of Ulsan	Seoul
Korea, Republic of	Hospital Ewha Womans University Mokdong	Seoul
Korea, Republic of	Hospital Severance, Yonsei University Health System	Seoul
Korea, Republic of	Samsung Medical Center, Sungkyunkwan University	Seoul
Korea, Republic of	Hospital Yonsei University Wonju Christian	Wonju
Korea, Republic of	Hospital Pusan National University of Yangsan	Yangsan
Mexico	Centenario Hospital Miguel Hidalgo	Aguascalientes
Mexico	Hospital Regional de Pemex	Ciudad Madero
Mexico	Hospital Mérida Yucatán	Mérida
Mexico	Hospital Ángeles de las Lomas	México DF
Mexico	Hospital Juárez de México	México DF
Mexico	Hospital Regional 1° de Octubre, ISSSTE	México DF
Mexico	Hospital Regional de Zona No.1 del IMSS	México DF
Mexico	Instituto Nacional de Cancerología	México DF
Mexico	Umae Hospital De Especialidades Dr. Antonio Fraga Mouret	México DF
Mexico	Hospital General de México	Mexico, DF
Mexico	Instituto Nacional De Ciencias Médicas y Nutrición Salvador Zubirán	Mexico, DF
Mexico	Centro Médico ABC	México, DF
Mexico	Hospital Español de México	Miguel Hidalgo
Mexico	Hospital Universitario de Nuevo León 'Dr. Eleuterio González'	Nuevo León
Mexico	Hospital Regional de Alta Especialidad de la Mujer	Villahermosa
Morocco	Hôpital des Specialites	Rabat
Morocco	Hôpital Ibn Sina (Three units)	Rabat
Morocco	Hôpital Militaire D'Instruction Mohamed V	Rabat
Netherlands	Onze Lieve Vrouwe Gasthuis (OLVG)	Amsterdam
Netherlands	Vrije Universiteit Medisch Centrum (VUMC) (Three units)	Amsterdam
Netherlands	Medisch Centrum Haaglanden	Den Haag
Netherlands	Kennemer Gasthuis	Haarlem
Netherlands	Tjongerschans Ziekenhuis	Heerenveen
Netherlands	Spaarneziekenhuis	Hoofddorp
Netherlands	Medical Center Leeuwarden (MCL)	Leeuwarden
Netherlands	Universitair Medisch Centrum Maastricht	Maastricht
New Zealand	CVICU Auckland City Hospital	Auckland
New Zealand	DCCM Auckland City Hospital	Auckland
New Zealand	Middlemore	Auckland
New Zealand	Christchurch Hospital	Christchurch
New Zealand	Waikato	Hamilton
New Zealand	Tauranga Hospital	Tauranga
New Zealand	Wellington Hospital	Wellington
Panama	Hospital Rafael Hernández	Chiriquí
Peru	Hospital Edgardo Rebagliatti Martins	Lima
Peru	Hospital Guillermo Almenara Irigoyen	Lima
Poland	Karol Marcinkowski University Of Medical Sciences	Poznan
Portugal	Hospital Garcia de Orta	Almada
Portugal	Hospital da Luz	Amadora
Portugal	Hospital de Cascais	Cascais
Portugal	Centro Hospitalar de Lisboa Central	Lisboa
Portugal	Centro Hospitalar de Lisboa Norte	Lisboa
Portugal	Hospital de Santo Antonio dos Capuchos, Centro Hospitalar de Lisboa Central, E.P.E.	Lisboa
Portugal	Centro Hospitalar Do Porto - Hospital Geral De Santo António	Porto
Portugal	Instituto Português de Oncología Francisco Gentil	Porto
Portugal	Hospital De São Sebastião	Seide
Portugal	Centro Hospitalar Trás-Os-Montes E Alto Douro	Vila-Real
Puerto Rico	VA Caribbean Health Care System	San Juan
Russian Federation	City Hospital Number 1 of Arkhangelsk	Arkhangelsk
Russian Federation	Hospital No.14	Ekaterinburg
Russian Federation	Hospital No.7	Moscow
Russian Federation	National Institute Of Surgery Named After A.V. Vishnevskij	Moscow
Saudi Arabia	King Saud Bin Abdulaziz University for Health Sciences	Riyadh
Spain	Hospital Juan Canalejo	A Coruña
Spain	Hospital General de Albacete	Albacete
Spain	Hospital Príncipe de Asturias	Alcalá de Henares
Spain	Fundación Hospital Universitario de Alcorcón	Alcorcón
Spain	Hospital General de Alicante	Alicante
Spain	Hospital San Juan	Alicante
Spain	Hospital Torrecárdenas	Almeria
Spain	Hospital del Tajo	Aranjuez
Spain	Hospital del Sureste	Arganda
Spain	Hospital San Agustín	Avilés
Spain	Hospital Germans Trias i Pujol	Badalona
Spain	Hospital de Cruces	Baracaldo
Spain	Hospital Clinic-IDIBAPS (ICU medical & ICU respiratory)	Barcelona
Spain	Hospital de la Santa Creu y Sant Pau	Barcelona
Spain	Hospital del Mar	Barcelona
Spain	Hospital Sagrado Corazón	Barcelona
Spain	Hospital SCIAS	Barcelona
Spain	Hospital San Pedro de Alcántara	Cáceres
Spain	Hospital Santa María del Rosell	Cartagena
Spain	Hospital de la Plana	Castellón De La Plana
Spain	Hospital General de Castellón	Castellón De La Plana
Spain	Hospital Provincial de Castellón	Castellón De La Plana
Spain	Complejo Hospitalario de Ciudad Real	Ciudad Real
Spain	Hospital Universitario Reina Sofia	Córdoba
Spain	Hospital del Henares	Coslada
Spain	Hospital de Don Benito	Don Benito
Spain	Hospital del Poniente	El Ejido
Spain	Hospital General Universitario de Elche	Elche
Spain	Hospital Arquitecto Marcide	Ferrol
Spain	Hospital de Fuenlabrada	Fuenlabrada
Spain	Hospital de Galdakao	Galdakao
Spain	Hospital Universitario de Getafe	Getafe
Spain	Hospital de Cabueñes	Gijón
Spain	Hospital Universitario Doctor Josep Trueta	Girona
Spain	Hospital Virgen de las Nieves	Granada
Spain	Hospital General de Guadalajara	Guadalajara
Spain	Hospital Juan Ramón Jimenez	Huelva
Spain	Complejo Hospitalario de Jaen	Jaen
Spain	Hospital General de Jerez de la Frontera	Jérez de la Frontera
Spain	Hospital General de La Palma	La Palma
Spain	Hospital Doctor Negrín	Las Palmas
Spain	Hospital Insular de Gran Canaria	Las Palmas
Spain	Complejo Hospitalario de León	León
Spain	Hospital Arnau de Vilanova	Lleida
Spain	Hospital de San Pedro	Logroño
Spain	Complejo Hospitalario Xeral-Calde	Lugo
Spain	Fundación Jiménez Díaz	Madrid
Spain	Hospital 12 de Octubre	Madrid
Spain	Hospital 12 de Octubre (Trauma ICU)	Madrid
Spain	Hospital Clínico San Carlos	Madrid
Spain	Hospital de la Princesa	Madrid
Spain	Hospital Gregorio Marañón	Madrid
Spain	Hospital Infanta Leonor	Madrid
Spain	Hospital Quirón	Madrid
Spain	Hospital Universitario de la Paz	Madrid
Spain	Hospital Universitario Puerta de Hierro	Majadahonda
Spain	Hospital Carlos Haya	Malaga
Spain	Hospital Universitario Virgen de la Victoria	Malaga
Spain	Hospital de Mataró	Mataró
Spain	Hospital de Móstoles	Móstoles
Spain	Hospital J .M. Morales Meseguer	Murcia
Spain	Hospital Universitario Reina Sofia	Murcia
Spain	Hospital Virgen de la Arrixaca	Murcia
Spain	Hospital Vega Baja de Orihuela	Orihuela
Spain	Complejo Hospitalario de Ourense	Ourense
Spain	Hospital Central de Asturias	Oviedo
Spain	Hospital Rio Carrión	Palencia
Spain	Hospital Son Llatzer	Palma De Mallorca
Spain	Hospital Universitario Son Espasses	Palma De Mallorca
Spain	Complejo Hospitalario de Navarra	Pamplona
Spain	Hospital Infanta Cristina	Parla
Spain	Complejo Hospitalario Montecelo	Pontevedra
Spain	Hospital Universitario de San Juan	Reus
Spain	Hospital Parc Taulí	Sabadell
Spain	Hospital de Sagunto	Sagunto
Spain	Complejo Hospitalario de Salamanca	Salamanca
Spain	Hospital Clínico de Salamanca	Salamanca
Spain	Complejo Hospitalario de Donostia	San Sebastian
Spain	Complejo Hospitalario de Santiago de Compostela	Santiago de Compostela
Spain	Hospital General de Segovia	Segovia
Spain	Hospital Universitario de Valme	Sevilla
Spain	Hospital Virgen del Rocío	Sevilla
Spain	Hospital General de Soria	Soria
Spain	Hospital Mutua de Terrassa	Terrassa
Spain	Hospital Obispo Polanco	Teruel
Spain	Complejo Hospitalario de Toledo	Toledo
Spain	Hospital de Torrevieja	Torrevieja
Spain	Hospital Infanta Elena	Valdemoro
Spain	Hospital Universitario de la Fe	Valencia
Spain	Hospital Universitario Dr. Peset	Valencia
Spain	Hospital Clínico de Valladolid	Valladolid
Spain	Hospital Rio Hortega	Valladolid
Spain	Hospital Meixoeiro	Vigo
Spain	Hospital Santiago Apóstol	Vitoria
Spain	Hospital Lluis Alcanyis	Xativa
Spain	Hospital de Zamora	Zamora
Spain	Hospital Clínico Lozano Blesa	Zaragoza
Spain	Hospital Royo Vilanova	Zaragoza
Taiwan	Chi Mei Medical Center	Tainan City
Tunisia	Hospital Abderrahmane Mami	Ariana
Tunisia	Hospital Taher Sfar City	Mahdia
Tunisia	Hospital Fattouma Bourguina (ICU medical & ICU surgical)	Monastir
Tunisia	CHU Habib Bourguiba	Sfax
Tunisia	Hospital Universitarie Farhat Hached	Sousse
Turkey	Uludag University Faculty of Medicine	Bursa
Turkey	Erciye Üniversity	Erciyes
Turkey	Anadolu Medical Center Istanbul	Istanbul
Turkey	Atatürk Hospital	Izmir
Turkey	Sutcu Imam University	Kahramanmaras
Turkey	Kirikkale University	Kirikkale
Turkey	Faculty of Medicine Mersin University	Mersin
Turkey	Medical Faculty of Yuzuncu Yil University	Van
United States	Boston Medical Center	Boston	Massachusetts
United States	Henry Ford Hospital Detroit	Detroit	Michigan
United States	University Of Texas Medical Branch at Galveston	Galveston	Texas
United States	University of Iowa Hospitals and Clinics	Iowa City	Iowa
United States	University of Louisville School of Medicine	Louisville	Kentucky
United States	Medical College Of Wisconsin	Milwaukee	Wisconsin
United States	Morristown Medical Center	Morristown	New Jersey
United States	Vanderbilt University School Of Medicine	Nashville	Tennessee
United States	Bronx Lebanon Hospital Center	New York	New York
United States	New York Methodist Hospital	New York	New York
United States	The Mount Sinai Medical Center	New York	New York
United States	UMDNJ-New Jersey Medical School	Newark	New Jersey
United States	Oklahoma City VA Medical Center	Oklahoma City	Oklahoma
United States	Oklahoma University Health Science Center & VA medical Center	Oklahoma City	Oklahoma
United States	Omaha VA Medical Center	Omaha	Nebraska
United States	University Hospital San Antonio and South Texas Veterans Health Care System	San Antonio	Texas
United States	Baystate Medical Center	Springfield	Massachusetts
United States	Temple Clinic, Scott & White Healthcare	Temple	Texas
Uruguay	CAAMOC Carmelo	Carmelo
Uruguay	Orameco	Colonia
Uruguay	Hospital de Florida	Florida
Uruguay	CRAMI	Las Piedras
Uruguay	Hospital de Maldonado	Maldonado
Uruguay	Sanatorio Mautone	Maldonado
Uruguay	Sanatorio CAMS	Mercedes
Uruguay	CASMU Nº2	Montevideo
Uruguay	Circulo Católico	Montevideo
Uruguay	CUDAM	Montevideo
Uruguay	Hospital de Clínicas	Montevideo
Uruguay	Hospital Español	Montevideo
Uruguay	Hospital Evangélico	Montevideo
Uruguay	Hospital Maciel	Montevideo
Uruguay	Hospital Pasteur	Montevideo
Uruguay	Hospital Policial	Montevideo
Uruguay	Impassa	Montevideo
Uruguay	Sanatorio Americano	Montevideo
Uruguay	CAAMEPA	Pando
Uruguay	COMEPA	Paysandú
Uruguay	Hospital Escuela del Litoral	Paysandú
Uruguay	Sanatorio Cantegril	Punta del Este
Venezuela	Hospital Centro de Especialidades	Anzoategui
Venezuela	Hospital Clínico Universitario	Caracas
Venezuela	Hospital de Clínicas	Caracas
Venezuela	Hospital Miguel Pérez Carreño	Caracas
Vietnam	Viet Duc Hospital	Hanoi

Sponsors (1)

Lead Sponsor	Collaborator
Hospital Universitario Getafe

Countries where clinical trial is conducted

United States,  Uruguay,  Venezuela,  Vietnam,  Argentina,  Australia,  Bolivia,  Brazil,  Canada,  Chile,  China,  Colombia,  Denmark,  Ecuador,  Egypt,  France,  Germany,  Greece,  Hungary,  India,  Italy,  Japan,  Korea, Republic of,  Mexico,  Morocco,  Netherlands,  New Zealand,  Panama,  Peru,  Poland,  Portugal,  Puerto Rico,  Russian Federation,  Saudi Arabia,  Spain,  Taiwan,  Tunisia,  Turkey, 

References & Publications (2)

Esteban A, Anzueto A, Frutos F, Alía I, Brochard L, Stewart TE, Benito S, Epstein SK, Apezteguía C, Nightingale P, Arroliga AC, Tobin MJ; Mechanical Ventilation International Study Group. Characteristics and outcomes in adult patients receiving mechanical ventilation: a 28-day international study. JAMA. 2002 Jan 16;287(3):345-55. — View Citation

Esteban A, Ferguson ND, Meade MO, Frutos-Vivar F, Apezteguia C, Brochard L, Raymondos K, Nin N, Hurtado J, Tomicic V, González M, Elizalde J, Nightingale P, Abroug F, Pelosi P, Arabi Y, Moreno R, Jibaja M, D'Empaire G, Sandi F, Matamis D, Montañez AM, Anzueto A; VENTILA Group. Evolution of mechanical ventilation in response to clinical research. Am J Respir Crit Care Med. 2008 Jan 15;177(2):170-7. Epub 2007 Oct 25. Review. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	All-cause Mortality	Mortality at discharge from intensive care unit	At day 28 after the beginning of mechanical ventilation