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Efficacy and Safety of Anakinra in Acute Respiratory Distress Syndrome — ESKA  

Acute Respiratory Distress Syndrome Clinical Trial

Official title:
Efficacy and Safety of Anakinra in Acute Respiratory Distress Syndrome

Clinical Trial Summary

Acute Respiratory Distress Syndrome (ARDS) is a life-threatening condition characterized by acute respiratory failure with hypoxemia, noncardiogenic or non-fluid overload pulmonary edema, bilateral diffuse opacities on chest radiograph in the presence of a predisposing factor. In ARDS there is activation of the inflammatory cascade which is very intense and persistent in the severe types. It was highlighted that the inflammatory cytokines in patients with ARDS or sepsis is similar to that observed in COVID-19 positive patients. Emerging therapies include immunomodulation and the administration of mesenchymal stem cells for the modulation of lung repair through the release of cytokines and growth factors that modulate the local inflammatory response. Regardless of the cause of ARDS, the severity of the inflammatory state and fibroproliferative evolution have been shown to be independent predictors of survival and ventilator dependence. Patients suffering from severe forms of ARDS in fact require prolonged mechanical ventilation, which exposes them to ventilator-associated pneumonia (VAP) and the onset of multiorgan insufficiency. The hyperinflammatory state underlying ARDS predisposes to pulmonary fibroproliferation, which in turn increases susceptibility to ventilator dependence and increases the risk of MOF and death. For this reason, the rationale in the use of anakinra is to limit the inflammatory process of ARDS as early as possible, avoiding the progression of lung damage.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05914454
Study type Interventional
Source Azienda Sanitaria-Universitaria Integrata di Udine
Contact Tiziana Bove, MD, PhD
Phone +39 0432559501
Email tiziana.bove@asufc.sanita.fvg.it
Status Recruiting
Phase Phase 2
Start date May 19, 2023
Completion date September 19, 2025
View Details
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