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Avalanche Phenomenon During Airways Opening in Acute Respiratory Distress Syndrome — AVALANCHE  

Acute Respiratory Distress Syndrome Clinical Trial

Official title:
Avalanche Phenomenon During Airways Opening in Acute Respiratory Distress Syndrome

Clinical Trial Summary

Acute respiratory distress syndrome accounts for 23% of mechanically ventilated patients and is associated with high mortality rate. Although life-saving, mechanical ventilation may worsen lung injury through two main mechanisms: lung overdistension and atelectrauma. Indeed, the cyclic opening and closure of airways during tidal ventilation may cause lung and bronchial injuries as suggested by animal models and autopsy findings. Complete airways closure has recently been described in 40% of patients with acute respiratory distress syndrome, and setting positive end-expiratory pressure above the airway opening pressure may limit atelectrauma. However, animal and mathematical models suggest that above the airway opening pressure, more distal airways open unevenly according to their own opening pressure, resulting in an "avalanche"-like phenomenon during lung inflation. This phenomenon has never been described in humans. A better understanding of the opening of airways in acute respiratory distress syndrome may help to limit ventilation-induced lung injury and to improve outcomes.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05224323
Study type Observational [Patient Registry]
Source Poitiers University Hospital
Contact Rémi Coudroy, MD, PhD
Phone + 33 5 49 44 40 07
Email remi.coudroy@chu-poitiers.fr
Status Recruiting
Phase
Start date March 1, 2022
Completion date September 2023
View Details
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