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Effects of Extravascular Lung Water on Prone Position Efficacy in Patients With ARDS

Acute Respiratory Distress Syndrome Clinical Trial

Official title:
Effects of Extravascular Lung Water on Prone Position Efficacy in Patients With Acute Respiratory Distress Syndrome

Clinical Trial Summary

The study will investigate the influence that extravascular lung water index (EVLWi) could have on the efficacy and persistance of efficacy of prone position in patients with acute respiratory distress syndrome. Prone position will increase blood oxygenation in 75% of the cases and will be persistant in half of the cases. Unfortunately, no clinical criteria has been found correlated with efficacy. The quantity of lung edema, with increased lung weight, could be a determinant factor of efficacy and the persistance of the efficacy. EVLWi, assessed with the PiCCO2 device, reflects the quantity of fluid accumulated in interstitial and alveolar spaces. The hypothesis is that patients with higher EVLWi will have less efficacy of prone position in oxygenation and also that the beneficial effects of prone position will last shorter compared to patients with lower EVLWi.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

  • Acute Lung Injury
  • Acute Respiratory Distress Syndrome
  • Acute Respiratory Distress Syndrome in Adult or Child
  • Respiratory Distress Syndrome, Adult
  • Respiratory Distress Syndrome, Newborn
  • Syndrome
Clinical Trial Details
NCT number NCT04635267
Study type Observational [Patient Registry]
Source Bicetre Hospital
Contact Xavier Monnet, MD, PhD
Phone +33-(0)6660862669
Email xavier.monnet@aphp.fr
Status Not yet recruiting
Phase
Start date January 1, 2021
Completion date May 1, 2022
View Details
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