Acute Respiratory Distress Syndrome Clinical Trial
Official title:
Strain and Blood Inflammatory Markers as Prognostic Tools for ARDS AMIS (ARDS - Markers of Inflammation - Strain)
The objective is determine the strain measured at the bedside could be a dynamic prognostic marker of during Acute respiratory Distress Syndrome (ARDS).
Nowadays ARDS severity, and therapeutic efficiency are evaluated using PaO2/FiO2 ratio.
Inflammation is a cornerstone of ARDS and the ratio is not a sufficiently accurate tool to
predict the evolution of ARDS. A reproducible marker would be helpful to adapt the
therapeutics and maybe limit their deleterious effects.
The investigators made the hypothesis that patients moderate to severe ARDS (comparable
PaO2/FiO2 ratio) with a higher strain may have higher inflammation.
Moderate/severe ARDS will be ventilate with protective ventilation (low tidal volume and PEEP
set to limit plateau pressure under 30cmH2O). Markers of inflammation will be measured in the
broncho Alveolar Lavage the first day and in the blood the following days. Strain will be
measured at the bedside using the nitrogen washout-washin. Markers of inflammation and strain
will be analysed with ventilatory and oxygenation.
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