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Effects of PEEP and FIO2 in ALI and ARDS — HELP  

Acute Respiratory Distress Syndrome Clinical Trial

Official title:
Effects of PEEP and FiO2 in the Evaluation of Severity of ALI and ARDS

Clinical Trial Summary

Current American-European Consensus Conference (AECC) definitions for ALI and ARDS are inadequate for inclusion into clinical trials due to the lack of standardization for measuring the oxygenation defect. We questioned whether an early assessment of oxygenation on specific ventilator settings would identify patients with established ARDS (persisting over 24h).

Clinical Trial Description

We designed this study to determine whether standard ventilator settings applied on the day ARDS is identified (Day 0) or 24 hours (Day 1) later: (1) would have an impact on the reclassification of patients into ALI or ARDS, and (2) would identify groups with different clinical outcomes. Our hypothesis was that the assessment of PaO2/FiO2 on standard ventilator settings 24 hours after patients originally met the AECC definition of ARDS would identify patients with established ARDS (persisting over 24 h) from others with different degrees of lung injury. If this hypothesis is supported, it would suggest that patients with a better outcome could have been preferentially entered into one group of previously conducted clinical trials, resulting in a viable therapy being proved useless or useless therapy proven viable. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00435110
Study type Observational
Source Instituto Canario de Investigacion Biomedica
Contact
Status Completed
Phase
Start date May 2004
Completion date October 2005
View Details
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