Acute Lung Injury Clinical Trial
Official title:
Nebulized Heparin for Prevention of Acute Lung Injury in Adult Patients Suffering Smoke Inhalation Injury: A Randomized Controlled Trial
This study aims to examine the value of nebulized heparin for prevention of acute lung injury in adult patients suffering smoke inhalation injury. Patients will be randomized to receive nebulized heparin or an equal volume of normal saline for 14 days and the incidence of acute lung injury will be compared in either group.
Adult patients who suffered smoke inhalation injury and who are candidates for elective intubation, have evidence of bronchial burn by fiberoptic bronchoscopy, have no evidence of acute lung injury and no more than 24 hours since inhalation injury will be included. Patients will be randomized into 2 groups: Group A (Intervention): Patients will receive 5000 IU heparin mixed with 3 ml saline and nebulized every 4 hours until they are extubated or until 14 days have elapsed whichever is earlier. Group B (Control): Patients will receive 4 ml of normal saline nebulized every 4 hours until they are extubated or until 14 days have elapsed whichever is earlier. Occurrence of acute lung injury will be assessed everyday for a maximum of 28 days. The primary end point is the occurrence of acute lung injury defined as defined by the Murray Lung Injury Score. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT03937947 -
Traumatic Brain Injury Associated Radiological DVT Incidence and Significance Study
|
||
Completed |
NCT04247477 -
Comparison of Different PEEP Titration Strategies Using Electrical Impedance Tomography in Patients With ARDS
|
N/A | |
Completed |
NCT03315702 -
Effect of Mechanical Ventilation on Plasma Concentration Level of R-spondin Proteins
|
||
Not yet recruiting |
NCT02693912 -
Changes in Alveolar Macrophage Function During Acute Lung Injury
|
N/A | |
Completed |
NCT01659307 -
The Effect of Aspirin on REducing iNflammation in Human in Vivo Model of Acute Lung Injury
|
Phase 2 | |
Unknown status |
NCT01186874 -
Epidemiology Research on Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) in Adult ICU in Shanghai
|
N/A | |
Completed |
NCT01552070 -
Recruitment on Extravascular Lung Water in Acute Respiratory Distress Syndrome (ARDS)
|
Phase 2 | |
Withdrawn |
NCT00961168 -
Work of Breathing and Mechanical Ventilation in Acute Lung Injury
|
N/A | |
Recruiting |
NCT00759590 -
Comparison of Two Methods to Estimate the Lung Recruitment
|
N/A | |
Completed |
NCT00736892 -
Incidence of Acute Lung Injury: The Alien Study
|
||
Completed |
NCT02475694 -
Acute Lung Injury After Cardiac Surgery: Pathogenesis
|
N/A | |
Completed |
NCT00825357 -
Biological Markers to Identify Early Sepsis and Acute Lung Injury
|
N/A | |
Terminated |
NCT00263146 -
Recruitment Maneuvers in ARDS: Effects on Respiratory Function and Inflammatory Markers.
|
N/A | |
Completed |
NCT00188058 -
Comparison of 2 Strategies of Adjustment of Mechanical Ventilation in Patients With Acute Respiratory Distress Syndrome
|
N/A | |
Completed |
NCT00234767 -
Study of the Economics of Pulmonary Artery Catheter Use in Patients With Acute Respiratory Distress Syndrome (ARDS)
|
Phase 3 | |
Recruiting |
NCT02598648 -
Role and Molecular Mechanism of Farnesoid X Receptor(FXR) and RIPK3 in the Formation of Acute Respiratory Distress Syndrome in Neonates
|
N/A | |
Recruiting |
NCT02948530 -
Measurement of Lung Elastance and Transpulmonary Pressure Using Two Different Methods (Lungbarometry)
|
||
Completed |
NCT01532024 -
Exploratory Clinical Study of Neutrophil Activation Probe (NAP) for Optical Molecular Imaging in Human Lungs
|
Early Phase 1 | |
Recruiting |
NCT01992237 -
Measuring Energy Expenditure in ECMO (Extracorporeal Membrane Oxygenation) Patients
|
N/A | |
Completed |
NCT01486342 -
PET Imaging in Patients at Risk for Acute Lung Injury
|
N/A |