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Measurement of Lung Elastance and Transpulmonary Pressure Using Two Different Methods (Lungbarometry)

Acute Lung Injury Clinical Trial

Official title:
Measurement of Lung Elastance and Transpulmonary Pressure Using Two Different Methods (Lungbarometry)

Clinical Trial Summary

Classically lung elastance and transpulmonary pressure are measured from the difference in tidal variations of airway pressure subtracted by tidal variations i esophagus pressure divided by the tidal volume. This requires the presence of a esophageal balloon catheter which is cumbersome and costly. In this study values obtained as described above are compared to values obtained with a new method in which a stepwise increase in positive endexpiratory pressure (PEEP) is performed with a size of the lung volume increase which corresponds to the tidal volume which the patient is ventilated with. The measurements are performed in sedated and mechanically ventilated patients in the intensive care unit.

Clinical Trial Description

Classically lung elastance and transpulmonary pressure are measured from the difference in tidal variations of airway pressure subtracted by tidal variations in esophageal pressure divided by the tidal volume (Method 1). This requires the presence of a esophageal balloon catheter which is cumbersome and costly.

In this study values obtained as described in Method 1 above are compared to values obtained with a new method (Method 2) in which a PEEP-step is performed with a size of the lung volume increase which corresponds to the tidal volume which the patient is ventilated with. Measurements using Method 1 and 2 are performed in sedated and mechanically ventilated patients in the intensive care unit. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02948530
Study type Observational
Source Sahlgrenska University Hospital, Sweden
Contact Stefan Lundin, MD, PhD
Phone +46313428112
Email stefan.lundin@gu.se
Status Recruiting
Phase
Start date October 2016
Completion date December 2018
View Details
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