Acute Lung Injury Clinical Trial
— ALIENOfficial title:
Acute Lung Injury: Epidemiology and Natural History. The ALIEN Study
NCT number | NCT00736892 |
Other study ID # | 2008-0915-EPI |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | September 2008 |
Est. completion date | May 2010 |
Verified date | October 2018 |
Source | Villar, Jesus, M.D. |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Acute lung injury is a clinical syndrome of rapid onset of acute respiratory failure. It represents a significant public health issue. Patients with acute lung injury require admission into critical care units for advanced life support and utilize considerable health care resources. Published epidemiological studies on acute lung injury in the last 20 years are difficult to compare because they used different definitions and length of time for evaluation. Less than five studies have collected information for an entire year, and none of them have evaluated the degree of oxygenation failure under standard settings. We will perform a one-year prospective audit of all patients admitted with acute lung injury in almost 40 ICUs in Spain.
Status | Completed |
Enrollment | 300 |
Est. completion date | May 2010 |
Est. primary completion date | March 2010 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria:American-European Consensus Conference Definition criteria for acute
lung injury:(i) rapid onset of acute lung injury not of cardiac origin; (ii) bilateral
pulmonary infiltrates on chest X ray; (iii) PaO2/FIO2<300 mmHg. Exclusion Criteria: None |
Country | Name | City | State |
---|---|---|---|
Spain | Hospital Universitario Dr. Negrin | Las Palmas de Gran Canaria | Canary Islands |
Lead Sponsor | Collaborator |
---|---|
Villar, Jesus, M.D. |
Spain,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Incidence of acute lung injury and the acute respiratory distress syndrome | 12 months | ||
Secondary | Risk factor associated with acute lung injury | 12 months | ||
Secondary | Mortality rates of acute lung injury, acute respiratory distress syndrome and combined | 12 months | ||
Secondary | Identification of clinical data associated with the highest or lowest mortality | 12 months |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT03937947 -
Traumatic Brain Injury Associated Radiological DVT Incidence and Significance Study
|
||
Completed |
NCT04247477 -
Comparison of Different PEEP Titration Strategies Using Electrical Impedance Tomography in Patients With ARDS
|
N/A | |
Completed |
NCT03315702 -
Effect of Mechanical Ventilation on Plasma Concentration Level of R-spondin Proteins
|
||
Not yet recruiting |
NCT02693912 -
Changes in Alveolar Macrophage Function During Acute Lung Injury
|
N/A | |
Completed |
NCT01659307 -
The Effect of Aspirin on REducing iNflammation in Human in Vivo Model of Acute Lung Injury
|
Phase 2 | |
Completed |
NCT01552070 -
Recruitment on Extravascular Lung Water in Acute Respiratory Distress Syndrome (ARDS)
|
Phase 2 | |
Unknown status |
NCT01186874 -
Epidemiology Research on Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) in Adult ICU in Shanghai
|
N/A | |
Withdrawn |
NCT00961168 -
Work of Breathing and Mechanical Ventilation in Acute Lung Injury
|
N/A | |
Recruiting |
NCT00759590 -
Comparison of Two Methods to Estimate the Lung Recruitment
|
N/A | |
Completed |
NCT02475694 -
Acute Lung Injury After Cardiac Surgery: Pathogenesis
|
N/A | |
Completed |
NCT00825357 -
Biological Markers to Identify Early Sepsis and Acute Lung Injury
|
N/A | |
Terminated |
NCT00263146 -
Recruitment Maneuvers in ARDS: Effects on Respiratory Function and Inflammatory Markers.
|
N/A | |
Completed |
NCT00188058 -
Comparison of 2 Strategies of Adjustment of Mechanical Ventilation in Patients With Acute Respiratory Distress Syndrome
|
N/A | |
Completed |
NCT00234767 -
Study of the Economics of Pulmonary Artery Catheter Use in Patients With Acute Respiratory Distress Syndrome (ARDS)
|
Phase 3 | |
Recruiting |
NCT02598648 -
Role and Molecular Mechanism of Farnesoid X Receptor(FXR) and RIPK3 in the Formation of Acute Respiratory Distress Syndrome in Neonates
|
N/A | |
Recruiting |
NCT02948530 -
Measurement of Lung Elastance and Transpulmonary Pressure Using Two Different Methods (Lungbarometry)
|
||
Completed |
NCT01532024 -
Exploratory Clinical Study of Neutrophil Activation Probe (NAP) for Optical Molecular Imaging in Human Lungs
|
Early Phase 1 | |
Recruiting |
NCT01992237 -
Measuring Energy Expenditure in ECMO (Extracorporeal Membrane Oxygenation) Patients
|
N/A | |
Completed |
NCT01486342 -
PET Imaging in Patients at Risk for Acute Lung Injury
|
N/A | |
Completed |
NCT01321398 -
Transpulmonary Pressure Gradients in High Frequency Oscillation
|
N/A |