Modulation of Lung Injury Complicating Lung Resection

Status Completed

Clinical Trial Summary

The purpose of this study is to determine whether N-acetylcysteine given intravenously 1 day pre-operatively is effective in preventing inflammation in the lungs, as measured by tests on blood, breath and lung specimens, in patients undergoing surgery to remove a portion of lung.

Clinical Trial Description

Acute lung injury occurs following lung resection in about 5% cases, and has a high mortality of around 50%. Management of these patients is largely supportive. Even in patients who do not develop clinical evidence of acute lung injury, markers of inflammation and oxidative stress are present in blood and exhaled breath condensate after lung resection. The purpose of this randomised double-blind placebo-controlled study is to determine whether lung injury can be prevented by pre-administration of N-acetylcysteine. ;

Study Design

Related Conditions & MeSH terms

Acute Lung Injury
Lung Injury
Respiratory Distress Syndrome, Adult
Wounds and Injuries

Clinical Trial Details

NCT number	NCT00655928
Study type	Interventional
Source	Imperial College London
Contact
Status	Completed
Phase	Phase 2
Start date	August 2007
Completion date	July 2009

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT03937947` - Traumatic Brain Injury Associated Radiological DVT Incidence and Significance Study
Completed	`NCT04247477` - Comparison of Different PEEP Titration Strategies Using Electrical Impedance Tomography in Patients With ARDS	N/A
Completed	`NCT03315702` - Effect of Mechanical Ventilation on Plasma Concentration Level of R-spondin Proteins
Not yet recruiting	`NCT02693912` - Changes in Alveolar Macrophage Function During Acute Lung Injury	N/A
Completed	`NCT01659307` - The Effect of Aspirin on REducing iNflammation in Human in Vivo Model of Acute Lung Injury	Phase 2
Completed	`NCT01552070` - Recruitment on Extravascular Lung Water in Acute Respiratory Distress Syndrome (ARDS)	Phase 2
Unknown status	`NCT01186874` - Epidemiology Research on Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) in Adult ICU in Shanghai	N/A
Withdrawn	`NCT00961168` - Work of Breathing and Mechanical Ventilation in Acute Lung Injury	N/A
Recruiting	`NCT00759590` - Comparison of Two Methods to Estimate the Lung Recruitment	N/A
Completed	`NCT02475694` - Acute Lung Injury After Cardiac Surgery: Pathogenesis	N/A
Completed	`NCT00736892` - Incidence of Acute Lung Injury: The Alien Study
Completed	`NCT00825357` - Biological Markers to Identify Early Sepsis and Acute Lung Injury	N/A
Terminated	`NCT00263146` - Recruitment Maneuvers in ARDS: Effects on Respiratory Function and Inflammatory Markers.	N/A
Completed	`NCT00188058` - Comparison of 2 Strategies of Adjustment of Mechanical Ventilation in Patients With Acute Respiratory Distress Syndrome	N/A
Completed	`NCT00234767` - Study of the Economics of Pulmonary Artery Catheter Use in Patients With Acute Respiratory Distress Syndrome (ARDS)	Phase 3
Recruiting	`NCT02598648` - Role and Molecular Mechanism of Farnesoid X Receptor(FXR) and RIPK3 in the Formation of Acute Respiratory Distress Syndrome in Neonates	N/A
Recruiting	`NCT02948530` - Measurement of Lung Elastance and Transpulmonary Pressure Using Two Different Methods (Lungbarometry)
Completed	`NCT01532024` - Exploratory Clinical Study of Neutrophil Activation Probe (NAP) for Optical Molecular Imaging in Human Lungs	Early Phase 1
Recruiting	`NCT01992237` - Measuring Energy Expenditure in ECMO (Extracorporeal Membrane Oxygenation) Patients	N/A
Completed	`NCT01486342` - PET Imaging in Patients at Risk for Acute Lung Injury	N/A