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Acute Lung Injury clinical trials

View clinical trials related to Acute Lung Injury.

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NCT ID: NCT05158842 Completed - Covid19 Clinical Trials

Treatment of COVID-19 Positive/Negative Bangladeshi Adults With Severe Respiratory Complaints by a Locally Made bCPAP: Feasibility Study

Adult-bCPAP
Start date: October 8, 2021
Phase: N/A
Study type: Interventional

Low and middle-income countries (LMICs) urgently need cost-effective adaptive technologies to provide CPAP. The lead investigator has designed a device that has already been approved by the Directorate General of Drug Administration (DGDA), Government of the People's Republic of Bangladesh. The design of the nasal seal was comfortable and well tolerated by all the participants. Patients were told about some mild discomfort at higher delivered pressures (14 or 15 cm PEEP), consistent with pressurised nasal delivery by similar devices. The safety phase has been initiated since 1st November 2020 and ended in April 2021. One patient withdrew from the study but none of them developed any adverse events. The feasibility phase started at the end of September 2021. Objectives: 1. To evaluate the barriers and operational challenges related to the introduction of adult bubble CPAP oxygen therapy 2. To evaluate the acceptability of introducing adult bubble CPAP in tertiary level hospitals of Bangladesh

NCT ID: NCT05137431 Completed - COVID-19 Pneumonia Clinical Trials

High-flow Nasal Oxygenation and Non-invasive Ventilation Strategies for the Treatment of Covid-19 Pneumonia

Start date: December 8, 2021
Phase:
Study type: Observational

HFNO and NIV strategies are the most commonly used strategies for the treatment of hypoxia in patients with a diagnosis of COVID-19 who are still followed in the intensive care unit, but there is no study comparing the two yet. In our prospective study, we aimed to compare these two treatment modalities. The primary goal is that the treatment is successful (weaned off HFNO/weaned off NIV: No need for HFNO or NIV and the patient recovers without the need for intubation). Failure will be evaluated as the need for intubation during treatment or the patient's death. Secondary aim is failure of treatment and discharge of patients from intensive care to service or home.

NCT ID: NCT05124197 Completed - Pressure Ulcer Clinical Trials

Extended Prone Position Duration COVID-19-related ARDS: a Retrospective Study

Start date: March 1, 2020
Phase:
Study type: Observational

Prone position (PP) is standard of care for mechanically ventilated patients with severe acute respiratory distress syndrome in the intensive care unit (ICU). Recommendations suggest PP durations of at least 16 hours. In 2020, COVID-19 pandemic led to a great number of patients requiring mechanical ventilation and PP in the ICU. Risk of ICU staff viral contamination and work overload led to prolongation of PP duration up to 48 hours. Here investigators report outcomes of prolonged PP sessions in terms of skin complications (pression injuries) and ventilatory improvement.

NCT ID: NCT05109624 Completed - Clinical trials for COVID-19 Acute Respiratory Distress Syndrome

Is Prolonged Period of Prone Position Effective and Safe in Mechanically Ventilated Patients With SARS-COV-2?

Start date: October 1, 2021
Phase: N/A
Study type: Interventional

the aim of the study is to assess safety and efficacy of prone position ventilation beyond the usual 16 hrs in patients with SARS-COV-2

NCT ID: NCT05102084 Completed - COVID-19 Clinical Trials

The Effect of Listening to Music During CPAP on the Agitation Levels and Compliance.

Start date: September 1, 2021
Phase: N/A
Study type: Interventional

Aim: This study was conducted to determine the effect of listening to music during CPAP on the agitation levels of intensive care patients who underwent CPAP due to COVID-19 and their compliance with the treatment. Study Design: This study is a prospective, randomized, controlled clinical trial. Seventy-six intensive care patients with COVID-19 were included in this study and assigned to the music and control groups via the block randomization method. The study was completed with 70 patients. In this study, the patients and outcome assessors were not blinded. The Richmond Agitation and Sedation Scale (RASS) level, respiratory rate, oxygen saturation (SpO2), and mask air leakage amount were the result criteria. Results: The mean RASS score of the patients in the intervention group was 2.14±0.69 before CPAP, 1.63±064 at the 1st minute, 0.89±0.58 at the 15th minute, and 0.74±0.61 at the 30th minute. The mean RASS score of the patients in the control group was 2.06±0.53 before CPAP, 1.80±0.58 at the 1st minute, 1.43±0.60 at the 15th minute, and 1.46±0.61 at the 30th minute of CPAP. There was a statistically significant difference between the groups at the 15th and 30th minutes (t=-3.81, p < .001; t=-4.89, p < .001, respectively).

NCT ID: NCT05092737 Completed - Clinical trials for Sars-CoV-2 Infection

Physiological Response to Prone Position in COVID-19 Associated Acute Respiratory Distress Syndrome (ARDS)

Start date: August 1, 2021
Phase:
Study type: Observational

Retrospective study in COVID-19 ARDS patients hospitalised in the ICU. Investigators aim to explore the effects of prone positioning on oxygenation, dead space ventilation and mortality.

NCT ID: NCT05091723 Completed - Clinical trials for Acute Lung Injury (ALI) Due to Coronavirus Disease-2019 (COVID-19)

TD-0903 Pharmacokinetics Study in Healthy Participants With Supplemental Oxygenation

Start date: October 13, 2021
Phase: Phase 1
Study type: Interventional

This is a Phase 1 pharmacokinetic (PK) study in healthy participants to assess the plasma pharmacokinetics, safety, and tolerability of a single inhaled dose of nezulcitinib (TD-0903) with supplemental oxygenation.

NCT ID: NCT05083130 Completed - COVID-19 Clinical Trials

Awake Prone Positioning in Moderate to Severe COVID-19

Start date: March 8, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is comparing vital signs between standard care and prone position groups. Standard care will consist of routine clinical care, including any advice to lie in prone position as routinely recommended by participating sites. For those randomized to prone position, a special intervention team will visit patients' rooms aiming for patients to maintain the prone position for at least 8 hours a day.

NCT ID: NCT05079009 Completed - Clinical trials for Acute Respiratory Distress Syndrome

Effects of Blood Pulsatility on Von Willebrand Factor During ECCO2R

FLOW-ECCO2R
Start date: January 28, 2022
Phase: N/A
Study type: Interventional

The primary objective of the study is to demonstrate that the ECCO2R pulsatile configuration prevents the Willebrand factor high molecular weight multimers decrease observed under continuous blood flow configurations. The secondary objectives are to quantify the CO2 extracorporeal removal in the pulsatile configuration, to describe complications (hemorrhagic, thrombotic and hemolytic), to describe patients' gas exchanges under ECCO2R, to describe the clinical course of the patients under ECCO2R as well as during the whole stay in the Intensive Care Unit (ICU).

NCT ID: NCT05077319 Completed - COVID-19 Clinical Trials

Characteristics and Outcome of Patients With COVID-19 in ICUs in South Tyrol

Start date: March 5, 2020
Phase:
Study type: Observational

The investigators retrospectively investigate the epidemiology, clinical characteristics and therapeutic interventions of patients with COVID-19 associated respiratory failure admitted to the intensive care units in South Tyrol, Italy.