Prediction of Acute Kidney Injury After Operation of Acute Type A Aortic Dissection Based on Multimodal Model

Acute Kidney Injury Clinical Trial

Official title:

Prediction of Acute Kidney Injury After Operation of Acute Type A Aortic Dissection Based on Multimodal Model

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05017896
• Other study ID #: 2020SDUCRCC031
• Status: Not yet recruiting
• Start date: September 2021
• Est. completion date: February 2023

Study information

• Verified date: August 2021
• Source: Qilu Hospital of Shandong University
• Contact: Xin Zhao
• Phone: +8618560086772
• Email: zhaoxin3617[@]163.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Acute kidney injury is one of the most common postoperative complications of acute type A aortic dissection, which is closely related to early postoperative death. Early prevention, early diagnosis and early treatment are the key to improve the prognosis of such patients. It has been a hot topic in clinical research for a long time. Previous reports revealed a series of risk factors for acute kidney injury after aortic dissection, but limited by research design and single modal data, high quality studies were rare. The purpose of this study is to further clarify the risk factors by studying the relationship between preoperative CT renal perfusion imaging indexes and postoperative acute kidney injury; establish and externally verify the multimodal radiomics prediction model for acute kidney injury after operation of aortic dissection combining with preoperative CT renal perfusion imaging and CT angiography information by analysis methods of information fusion, feature engineering and radiomics, so as to guide the follow-up clinical practice, improve the prognosis of such patients and save medical resources.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 242
• Est. completion date: February 2023
• Est. primary completion date: January 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

1. 18-70 years old

2. Acute type A aortic dissection diagnosed by CT angiography

3. Sign informed consent

Exclusion Criteria:

1. History of chronic kidney disease

2. History of cardiovascular operation

3. Acute kidney injury has occurred before operation

4. Pregnancy status

Related Conditions & MeSH terms

• Acute Kidney Injury
• Aneurysm
• Aneurysm, Dissecting
• Wounds and Injuries

Intervention

Diagnostic Test:
• Normal CT Renal Perfusion imaging indexes
A CT imaging which indicates the status of renal perfusion is normal.
• Low CT Renal Perfusion imaging indexes
A CT imaging which indicates the status of renal perfusion is low.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Qilu Hospital of Shandong University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Acute kidney injury after operation	Yes; No	From date of operation until the date of acute kidney injury or date of death from any cause, whichever came first, assessed up to 30 days.