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Transcriptional and Proteomic Analysis of Acute Kidney Injury — TPA-AKI  

Acute Kidney Injury Clinical Trial

Official title:
Transcriptional and Proteomic Analysis of Acute Kidney Injury

Clinical Trial Summary

Acute kidney injury is associated with worsened outcome for critically ill patients. Sepsis-associated and non-septic cardiothoracic surgery associated AKI have been reported, nonetheless, precise pathomechanistic differences as well as detectability of transcriptional and proteomic changes in correlation with imaging and plasma markers are unclear.

Clinical Trial Description

Acute kidney injury is a common and detrimental finding in critically ill/sepsis patients as well as non-septic patients post cardiothoracic surgery. In many cases renal replacement therapy is required and an acute kidney injury is linked to increased morbidity and mortality in intensive care patients. Using routinely obtained clinical samples as well as imaging data, this observational trial investigates the transcriptomic and proteomic determinants detectable in septic and non-septic AKI patient subsets and their correlation with outcome and AKI diagnostic parameters. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06064305
Study type Observational
Source University Hospital Muenster
Contact Alexander Zarbock, MD
Phone +4925183
Email zarbock@uni-muenster.de
Status Not yet recruiting
Phase
Start date September 29, 2023
Completion date December 1, 2024
View Details
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