Acute Ischemic Stroke Clinical Trial
Official title:
Predictive Factors of Outcome of Mechanical Thrombectomy After Acute Ischemic Stroke
Predictive factors of outcome of mechanical thrombectomy after acute ischemic stroke
Acute ischemic stroke is one of the most common causes of disability, dementia and death in
developing world. In Egypt, the total lifetime prevalence of ischemic stroke was 7.2/1,000 in
the population aged 20 years and more . Although the intravenous thrombolysis is a treatment
option within ≤ 4.5 hours after stroke onset, the mechanical thrombectomy can be performed
within a more extended time window. A positive results of 5 recent randomized clinical trials
are driven mainly from patients treated by mechanical thrombectomy within 6 hours from onset
and they demonstrated a clear benefit for mechanical thrombectomy in combination with
intravenous thrombolysis. More recent two randomized clinical trials DAWN and DEFUSE 3
demonstrated an overall benefit in functional outcome at 90 days in patients treated with
mechanical thrombectomy within 6 to 24 hours or 6 to 16 hours form onset respectively with
special criteria. A major issue remains as to identifying patients which likely to benefit
from mechanical thrombectomy to improve selection and subsequently clinical prognosis .
These factors include:-
1. Time of presentation.
2. Age.
3. Clinical presentation.
4. Risk factors include Hyperglycemia, peripheral vessel disease, atrial fibrillation,
coronary heart disease, hyperlipidemia, smoking, and history of pervious stroke,
5. Socioeconomic status.
6. Collateral and stroke core. In this study the investigators will evaluate prognostic
factors influencing angiographic and clinical outcomes at discharge and at three months
after mechanical thrombectomy of acute ischemic stroke within 24 hours.
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