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Acute Ischemic Stroke clinical trials

View clinical trials related to Acute Ischemic Stroke.

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NCT ID: NCT06240468 Recruiting - Clinical trials for Acute Ischemic Stroke

Dynamic Changes in Human Microbiome Predict the Risk of Adverse Outcomes in Patients With Acute Ischemic Stroke: a Multicenter Prospective Cohort Study

Start date: February 10, 2022
Phase:
Study type: Observational

(1) The main purpose To explore the predictive value of human microbiome and its metabolome for adverse prognosis in patients with acute ischemic stroke (AIS). (2) Secondary purposes 1. To explore the characteristics of cross-regional disturbance of human microbiome in stroke patients; 2. To investigate the characteristics and rules of bacterial flora changes before and after recurrent apoplexy; 3. Markers closely related to AIS prognosis and cognitive emotional complications were excavated by metagenomic, metabolic, peptide and imaging groups. 4. To explore the relationship between serum markers of ultra early stage and prognosis.

NCT ID: NCT06236828 Completed - Stroke Clinical Trials

The MRI-based Evaluation of Safety and Efficacy of EVT and SMT: A Retrospective, Multicenter Study

Start date: January 31, 2023
Phase:
Study type: Observational

Acute Basilar Artery Occlusion (ABAO), a condition with a high risk of mortality or disability (up to 80%). The safety and efficacy of endovascular thrombectomy (EVT) in ABAO remains uncertain due to inconsistent evidence from random controlled trials (RCTs). Recent studies have explored the use of MRI in ABAO, this study aims to assess the efficacy and safety of EVT and standard medical therapy (SMT) in the treatment of ABAO within 24 hours of onset. It also aims to explore the feasibility and prognostic value of MRI-based assessment of ABAO infarction using AI image analysis software.

NCT ID: NCT06226805 Not yet recruiting - Clinical trials for Acute Ischemic Stroke

Study of BB-031 in Acute Ischemic Stroke Patients (RAISE)

RAISE
Start date: June 2024
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the safety and tolerability of ascending doses (Part A) and selected doses (Part B) of BB-031 in acute ischemic stroke patients presenting within 24 hours of stroke onset. Participants will be randomized to receive one dose of either the investigational drug or placebo and will be followed for 90 days. A total of 156 patients are planned in this study.

NCT ID: NCT06220981 Recruiting - Clinical trials for Acute Ischemic Stroke

The Oslo Acute Reperfusion Stroke Study (OSCAR)

OSCAR
Start date: January 10, 2017
Phase:
Study type: Observational [Patient Registry]

Prospective registry of clinical and radiological data in acute ischemic stroke patients after endovascular treatment.

NCT ID: NCT06211712 Not yet recruiting - Clinical trials for Acute Ischemic Stroke

Efficacy and Safety of Human Urinary Kallidinogenase Combined With Endovascular Therapy in Acute Ischemic Stroke With Large Vessel Occlusion

HEAL
Start date: January 2024
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the safety and efficacy of Human Urinary Kallidinogenase combined with endovascular therapy in acute ischemic stroke (AIS) patients with large vessel occlusion.

NCT ID: NCT06202378 Recruiting - Clinical trials for Acute Ischemic Stroke

Safety and Efficacy of SHPL-49 Injection in Participants With Acute Ischemic Stroke

Start date: December 28, 2023
Phase: Phase 2
Study type: Interventional

This study is designed to determine the safety and efficacy of SHPL-49 intravenous infusion for 7 consecutive days in the treatment of acute ischemic stroke subjects.

NCT ID: NCT06200753 Recruiting - Clinical trials for Acute Ischemic Stroke

Triage of Patients Presenting Beyond 24 Hours With Acute Ischemic Stroke Due to Large Vessel Occlusions (TRACK-LVO Late)

TRACK-LVO Late
Start date: January 1, 2018
Phase:
Study type: Observational

The objective of this study is to create a comprehensive, multi-center, TRACK-LVO registry-linked cohort of consecutive patients with acute ischemic stroke (AIS) caused by large vessel occlusions (LVO) and presenting to each participating center beyond 24 hours from last known well, who are treated with either endovascular therapy (EVT) or the best available medical management (BMM).

NCT ID: NCT06194968 Recruiting - Clinical trials for Acute Ischemic Stroke

Treatment of Acute Ischemic StroKe With Intravenous UroKinase Real-world Research: a Multicenter, Prospective Study

Start date: December 30, 2023
Phase:
Study type: Observational

The purpose of this study is to to compare the safety and effectiveness of IV urokinase with IV alteplase in the treatment of AIS in patients up to 6 hours from symptom onset.

NCT ID: NCT06176872 Not yet recruiting - Clinical trials for Coronary Artery Disease

Cardiac CT Angiography in Patients With Acute Ischemic Stroke

ACUTE
Start date: January 1, 2024
Phase:
Study type: Observational

Mortality rates after acute ischemic stroke remain high despite continuously improving treatment. In this context, it is important to note that a relevant portion of acute ischemic stroke patients die from adverse cardiovascular events, such as myocardial infarction, rather than from complications associated with the stroke itself. A possible reason might be that this patient group often suffers from at least moderate asymptomatic coronary artery disease. This study seeks to integrate cardiac computed tomography angiography into the standard-of-care diagnostic protocol of acute ischemic stroke. The aim of this prospective mono-centric trial is to enable accurate diagnosis of therapy-relevant coronary artery disease, other concomitant cardiac findings and cardiac causes of acute ischemic stroke, without delaying stroke therapy. In the long-run, the goal is to investigate whether cardiac computed tomography angiography and the resulting therapeutic measures (interventions or medications added) can improve functional outcome and rate of adverse cardiac complications in patients with acute ischemic stroke compared to a retrospective matched-cohort of patients without cardiac CT imaging.

NCT ID: NCT06175715 Not yet recruiting - Clinical trials for Acute Ischemic Stroke

Regional or General Anesthesia for Carotid Endarterectomy in Patients With Acute Stage of Ischemic Stroke.

Start date: April 1, 2024
Phase: N/A
Study type: Interventional

The study is planned to evaluate the effectiveness and safety of two types of anesthesia (regional and general) for carotid endarterectomy in 100 patients with acute stage of stroke: 50 patients will be operated under regional anesthesia and the remaining 50 patients under general anesthesia. Patient inclusion criteria: 1. Ischemic stroke in the middle cerebral artery territory 2. Ipsilateral stenosis of the internal carotid artery more than 50% 3. Neurological deficit at the time of surgical treatment: the modified Rankin scale (mRs) score of 0-4 and the US National Institutes of Health (NIHSS) stroke scale score no more than 12 4. The size of the ischemia focus: no more than 1/3 in the territory of the middle cerebral artery brain supply 5. Terms of operation: from 1 to 28 days from the moment of ischemic stroke The primary intra-hospital and/or 30-day study endpoints: 1. Perioperative ipsilateral ischemic stroke. 2. Any stroke: contralateral ischemic or any hemorrhagic stroke. 3. Myocardial infarction. 4. Hemorrhagic complications that required surgical revision of the operating wound or transfusion of blood components. 5. Surgical site infection 6. Death 7. Main adverse cardiovascular events (stroke + myocardial infarction + death).