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Weaning Protocol for High-flow Nasal Oxygen Therapy in Intensive Care — HiFloWEAN  

Acute Hypoxemic Respiratory Failure Clinical Trial

Official title:
Weaning Protocol for High-flow Nasal Oxygen Therapy in Intensive Care: A Multicentre Randomised Controlled Trial

Clinical Trial Summary

High-flow nasal oxygen therapy (HFNO) is an oxygenation technique frequently used in intensive care. The main objective of our study is to show that the use of a protocol for weaning patients off high-flow nasal oxygen therapy (HFNO) in the intensive care unit increases the probability that patients will be weaned from HFNO at Day 7 post-randomisation. This is a open-label multicentre randomised controlled trial conducted in two parallel groups. The primary endpoint is the success rate at Day 7, with success defined as "definitive" weaning from HFNO, i.e. patients weaned from HFNO for more than 48 hours without recourse to non-invasive ventilation (NIV) or intubation and still alive at Day 7. The weaning protocol will be started as soon as the patient meets all the inclusion criteria, considered to be the prerequisites for initiating weaning from HFNO. Patients will be monitored until Day 28 maximum.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06104956
Study type Interventional
Source University Hospital, Tours
Contact Mai-Anh NAY, MD
Phone 02.38.51.44.46
Email mai-anh.nay@chr-orleans.fr
Status Recruiting
Phase N/A
Start date February 17, 2024
Completion date March 2027
View Details
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