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ROX Index for the Timing of Intubation in Nasal High Flow — ROX-1  

Acute Hypoxemic Respiratory Failure Clinical Trial

Official title:
ROX Index Compared to Standard of Care for the Timing of Intubation in Patients Supported by Nasal High Flow: a Randomized Controlled Trial

Clinical Trial Summary

Late or delayed intubation in patients with acute hypoxemic respiratory failure (AHRF) treated with nasal high flow (NHF) is associated with increased patient mortality. The ROX index has been designed and validated to predict outcome of NFH therapy by identifying those patients with a high risk of NHF failure and those with a high probability of success. Whether or not the ROX index may improve patient outcome remains to be shown. To do so, a strategy using the ROX index must lead to earlier intubation than commonly-used criteria. The objective of the ROX-1 trial is to assess whether the use of an algorithm incorporating the ROX index to standard of care for the time to intubation in patients with AHRF supported with NHF isassociated with an increase in the proportion of patients who are intubated within the first 12 hours among those patients who fail on NHF.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04707729
Study type Interventional
Source Hospital Universitari Vall d'Hebron Research Institute
Contact Oriol Roca, MD PhD
Phone +34932746209
Email oroca@vhebron.net
Status Recruiting
Phase N/A
Start date December 9, 2020
Completion date December 31, 2022
View Details
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