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Pharmacokinetics of Levosimendan in Pediatric Intensive Care Units — PALMAréa  

Acute Heart Failure Clinical Trial

Official title:
Pharmacokinetics of Levosimendan, OR1855 and OR1896 in Neonates and Children With or Without Extracorporeal Membrane Oxygenation

Clinical Trial Summary

To describe pharmacokinetics of levosimendan in neonates and children supported or not with extracorporeal circulation devices (ECMO, CRRT)

Clinical Trial Description

Levosimendan is a calcium sensitiver wih inotropic effects. It's use in the context of acute or chronic heart failure in children has yet to be defined. Due to physical proprieties of levosimendan and metabolites, we hypothesized that concomitant use of extracorporeal devices such as ECMO will cause major pharmacokinetic variations. Furthermore, pharmacokinetics of levosimendan in children with multiple organ failure has to be specify. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03681379
Study type Observational
Source Nantes University Hospital
Contact
Status Not yet recruiting
Phase
Start date October 1, 2018
Completion date October 1, 2020
View Details
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