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Clinical Trial Summary

Introduction: Recent studies have suggested that the use of acetazolamide may assist in the vol- ume management of patients with decompensated heart failure (HF). However, prospective and randomized comparison in patients with HF and optimized diuretic therapy has not been described. Objective: The aim of this study was to evaluate the effectiveness and safety of the use of acetazolamide versus placebo in volume control in patients with decompensated HF. Methodology: For this, a unicentric, randomized, double blind and prospective study will be performed in a comparative manner. Hospital data (test results, medical outcomes, drug dose, complications) of patients will be analyzed for safety and effectiveness. Expected results: The use of acetazolamide as an adjuvant treatment is superior to the standard strategy for volume control in patients with decompensated HF.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03720288
Study type Interventional
Source University of Sao Paulo General Hospital
Contact Alexandre Soeiro, MD
Phone +551126615299
Email alexandre.soeiro@bol.com.br
Status Recruiting
Phase Phase 3
Start date October 1, 2018
Completion date October 1, 2020

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