High VS Low Flow Nasal O2 for Acute Hypercapnic Respiratory Failure

Status Recruiting

Clinical Trial Summary

Chronic lung conditions such as smoking related lung damage lead to breathing fail. This results in accumulation of gases such as carbon-di-oxide in the body especially during periods of illness known as exacerbation. Current management of carbon-di-oxide accumulation is administration of oxygen, nebulisers, antibiotics etc and if necessary, provide a tight fitting mask around the face to provide breathing support. If this fails, then a patient is placed on a mechanical ventilator. The tight fitting mask therapy is also called non-invasive ventilation and is used widely but patients acceptability of the therapy is limited. Providing a high flow of air with some oxygen could potentially provide the same benefit of the non-invasive ventilation and may also be better accepted by patients. Currently the knowledge and evidence from studies suggest a beneficial role for this high flow therapy but this has not been investigated in well designed studies. In the proposed study we aim to investigate whether use of the high flow therapy reduces the need for non-invasive ventilation in patients who present with a recent onset accumulation of carbon-di-oxide in their body due to long-term lung disease. If this shows benefit, it will lead to a bigger trial with patient benefiting by reduction in the non-invasive ventilation or indeed a need for an invasive breathing machine.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Acute Exacerbation of COPD
Acute Hypercapnic Respiratory Failure
Hypercapnia
Respiratory Insufficiency

Clinical Trial Details

NCT number	NCT04640948
Study type	Interventional
Source	Belfast Health and Social Care Trust
Contact	Murali Shyamsundar, MD, PhD
Phone	+44 (0)28 9097 6381
Email	Murali.Shyamsundar@qub.ac.uk
Status	Recruiting
Phase	N/A
Start date	June 13, 2021
Completion date	March 2023

View Details

See also
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