Homocysteine in Acute Coronary Syndrome

Acute Coronary Syndrome Clinical Trial

Official title:

Serum Homocysteine Level in the Setting of Acute Coronary Syndrome in Young Adult Patients

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05125419
• Other study ID #: Homocysteine level
• Status: Completed
• Start date: November 30, 2021
• Est. completion date: July 1, 2023

Study information

• Verified date: July 2023
• Source: Sohag University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

This study aims to determine the relation between high homocysteine levels and increased incidence of acute coronary syndrome in young patients

Description:

Cross sectional study to:

assess homocysteine level in young adult patients presenting with acute coronary syndrome

Recruitment information / eligibility

• Status: Completed
• Enrollment: 100
• Est. completion date: July 1, 2023
• Est. primary completion date: May 30, 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

1. - The patients who presented in the hospital with chest pain consistent with acute coronary syndrome with any of the following features:

1. Electrocardiogram (ECG) changes:

• ST elevation

• ST depression

• T wave inversion

• recent left bundle branch block

2. Troponin T elevation (Norma value < 0.06)

2- Age: -Between 18- 40 years (Group A) - Age > 40 years (Group B)

Exclusion Criteria:

1. Chest pain not consistent with acute coronary syndrome

2. Chronic kidney disease (CKD)

3. Rheumatic heart disease (RHD)

4. Congenital heart disease

5. Anemia

6. Cancer

Related Conditions & MeSH terms

• Acute Coronary Syndrome
• Syndrome

Intervention

Diagnostic Test:
• Homocysteine level
diagnostic test

Locations

Country	Name	City	State
Egypt	Sohag University	Sohag

Sponsors (1)

Lead Sponsor	Collaborator
Sohag University

Country where clinical trial is conducted

Egypt, 

References & Publications (1)

Liu J, Quan J, Li Y, Wu Y, Yang L. Blood homocysteine levels could predict major adverse cardiac events in patients with acute coronary syndrome: A STROBE-compliant observational study. Medicine (Baltimore). 2018 Oct;97(40):e12626. doi: 10.1097/MD.0000000000012626. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Coronary care unit admission with acute coronary syndrome	Acute coronary syndrome hospitalization and cardiovascular deathes and estimated hazard ratios (HR) by use of multivariable Cox regression models	From date of randomization up to 1 month