Acute Coronary Syndrome Clinical Trial
Official title:
Clopidogrel or Ticagrelor in Acute Coronary Syndrome Patients Treated With Newer-Generation Drug-Eluting Stents: CHANGE DAPT
Acute coronary syndrome (ACS) guidelines have been changed, favoring dual antiplatelet
therapy (DAPT) with the more potent P2Y12 inhibitor ticagrelor over clopidogrel (besides
aspirin). This change is based on studies that showed benefits of ticagrelor. However, study
participants were only partly treated by percutaneous coronary intervention (PCI). In
patients who were treated by PCI, this was generally performed using of bare metal or
first-generation drug-eluting stents (DES).
CHANGE DAPT is an investigator-initiated, prospective, single centre registry, in which we
evaluate the impact of the guideline suggested change in the primary DAPT regimen (from
clopidogrel to ticagrelor) on 1-year clinical outcome in ACS patients treated by PCI with
newer-generation DES in the Thoraxcentrum Twente.
n/a
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